Destroying senescent cells in the aging stem cell niche enhances hippocampal neurogenesis and cognitive function in mice, researchers report January 20 in the journal Stem Cell Reports.
Jan 20, 2022
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Mayo Clinic researchers have uncovered three new agents to add to the emerging repertoire of drugs that aim to delay the onset of aging by targeting senescent cells - cells that contribute to frailty and other age-related ...
Mar 9, 2017
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How well women with cervical cancer respond to treatment and survive correlates with the level of 10 proteins in their blood that also are associated with a "zombie" cell state called senescence, Medical College of Georgia ...
Dec 7, 2020
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Finding new drugs—called "drug discovery"—is an expensive and time-consuming task. But a type of artificial intelligence called machine learning can massively accelerate the process and do the job for a fraction of the ...
Jul 7, 2023
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A new research paper titled "Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex" has been published in Aging.
Jun 13, 2023
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A study from The Wistar Institute demonstrated that NAMPT, an enzyme critical for NAD+ biosynthesis, mediates selection of stem-like chemoresistant cells following cisplatin treatment. Researchers showed that a combination ...
Dec 20, 2019
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Resting cancer cells can be selectively destroyed by inhibiting their energy metabolism. This is the recent discovery by researchers at Charité Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine ...
Sep 4, 2013
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A new research paper titled "Gene expression signatures of human senescent corneal and conjunctival epithelial cells" has been published in Aging.
Oct 2, 2023
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Most cells can divide only a limited number of times and eventually undergo permanent cell cycle arrest, a state known as cellular senescence. Cellular senescence is mediated by activation of specific cellular signaling pathways ...
Aug 4, 2016
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The gene SPOP is mutated in up to 15 percent of all cases of prostate cancer, making it one of the most mutated genes in the disease. However, when the gene is functioning properly, it acts as a tumor suppressor. Despite ...
Oct 29, 2015
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