Medical research

Receptors under flow: Mechanosensitive GPCRs

An LMU team has clarified how a receptor which is involved in the regulation of vital physiological processes senses the mechanical forces that act on blood vessels. The findings could suggest new therapies for diseases of ...

Cardiology

Mapping shear stress can help predict heart attacks

A heart attack is like an earthquake. When a patient is having a heart attack, it's easy for cardiologists to look at a coronary artery and identify the blockages that are causing trouble. However, predicting exactly where ...

Medical research

Gut response to fluid flow

Flow of fluids through the gut, such as milk from an infant's diet, generates a shear stress on cells lining the intestine. Ken Lau, Ph.D., and colleagues have demonstrated that microvilli – finger-like membrane protrusions ...

Medical research

Demystifying mechanotransduction ion channels

As blood flows through our vessels, the cells that constitute these vessels responds to the shear stress of blood flow to ensure normal circulation. This process of converting a mechanical force into a biological function ...