Medical research

Getting to the heart of heart muscle function

Every heart muscle cell, or cardiomyocyte, is studded with tiny, intricate structures called dyads. The dyads are like orchestra conductors: They coordinate incoming electrical signals with release of calcium in the muscle, ...

Alzheimer's disease & dementia

Untangling the role of tau in Alzheimer's disease

Alzheimer's disease is a brain disorder that causes neurons to die, slowly destroying memory and thinking skills. It's the most common type of dementia, impacting an estimated 50 million people worldwide, and is a particularly ...

Oncology & Cancer

Boosting the immune response against cancer

T cells are usually good at eliminating diseased cells, but they seem to fail when it comes to tumor cells. In JCI Insight, MDC teams led by Armin Rehm and Uta Höpken describe what inhibits this immune function, and how ...

Medical research

Inhibiting angiogenesis to treat cancer

Blood vessels are the body's essential architecture that exists in order to nurture cells with sufficient nutrients and oxygen. Angiogenesis, or the formation of new blood vessels, is of great research interest in cancer ...

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