Using human "mini-brain" models known as organoids, Mayo Clinic and Yale University scientists have discovered that the roots of autism spectrum disorder may be associated with an imbalance of specific neurons that play a ...
Aug 10, 2023
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Blood stem cells from healthy people carry major chromosomal alterations, suggesting we are all genetic mosaics, according to a new study from EMBL and the Max Delbrück Center.
May 28, 2024
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The gene SYNGAP1, the variants of which are top risk factors for Autism Spectrum Disorder (ASD), has previously unappreciated effects on the developing brain, according to a new study published in Nature Neuroscience. The ...
Nov 9, 2023
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A genetic disorder in PRDM6 causes patent ductus arteriosus (PDA), a congenital heart defect common in premature infants—suggesting a potential target for the treatment of congenital heart diseases.
Feb 14, 2022
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By introducing cancer-causing mutations into healthy skin cells step-by-step, Broad scientists have created models of skin cancer that can reveal the effects of mutations.
Apr 29, 2022
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One protein, Piezo1, is key to marshalling muscle stem cells' unique shapes and response to injuries, but it is in low supply in those with Duchenne muscular dystrophy, according to a team at the Perelman School of Medicine ...
Mar 18, 2022
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Using new genetic tools to study statins in human cells and mice, Stanford Medicine researchers and collaborators have uncovered how the cholesterol-lowering drugs protect the cells that line blood vessels.
May 11, 2023
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An experimental stem cell therapy can essentially cure type 1 diabetes by restoring insulin production in some patients, early clinical trial results show.
Jun 25, 2024
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Researchers led by the Francis Crick Institute have found that blocking a particular protein could offer a new way to target leukemic stem cells without causing harm to healthy stem cells.
Jun 23, 2022
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Pregnancy and motherhood lead to brain remodeling. A research team at the University of Basel has now discovered through experiments with mice that distinct pools of stem cells in the adult brain are turned on during pregnancy. ...
Nov 27, 2023
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