When your body fights off an infection, you develop a fever. If you have arthritis, your joints will hurt. If a bee stings your hand, your hand will swell up and become stiff. These are all manifestations of inflammation ...
Nov 7, 2022
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Stimulator of interferon genes, or STING, helps regulate immune activation. Thus, a research team is testing drugs that activate STING as a form of cancer immunotherapy and for treating certain infections. Findings from ...
Aug 10, 2022
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Immunotherapy has revolutionized treatment for many forms of cancer, but glioblastoma multiforme (GBM), the most common and deadly form of brain cancer, has remained untouched. GBM tumors are sometimes referred to as "cold"—that ...
Jul 11, 2022
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Innovations in cancer immunotherapy have achieved clinical success by considerably increasing the survival rate of patients undergoing cancer treatment. However, there still exists an unmet medical need due to the low response ...
May 31, 2022
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In studies with mouse and human tissue, as well as live mice, Johns Hopkins Medicine researchers report that a snag in the normal process of cleaning up broken DNA in brain cells may hasten the progression of Parkinson's ...
May 19, 2022
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Imaging at near-atomic resolution of a key immune protein commonly known as STING has revealed a previously unrecognized binding site that appears to be pivotal for launching immune attacks, UT Southwestern scientists report ...
Apr 7, 2022
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A new study from scientists at the UCLA Jonsson Comprehensive Cancer Center found that emerging drugs that activate the protein STING, a well-established regulator of immune cell activation, substantially alter the activity ...
Sep 7, 2021
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UT Southwestern researchers have identified an immune protein tied to the rare neurodegenerative condition known as Niemann-Pick disease type C. The finding, made in mouse models and published online in Nature, could offer ...
Jul 21, 2021
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The molecular world is full of surprises, and none more stunning than those occurring among the infinitesimal proteins that drive the activities guarding against viral infections and cancer.
A dysfunctional immune system significantly contributes to the development of cancer. Several therapeutic strategies to activate the immune system to target cancer cells have been approved to treat different types of cancer, ...
Apr 8, 2021
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