Medical research

When neurons behave like a double-edged sword

A new study reports that immune cell responses to bacteria affect the intrinsic excitability of rat neuronal subtypes differently. The findings have implications for neural network control, including irregularities that lead ...

Psychology & Psychiatry

Star cells in the brain render memory flexible

As we live in a dynamically changing environment, it is important for our brain to not only learn new things but also to modify existing memories. This is commonly referred to as "cognitive flexibility." Without this ability, ...

Neuroscience

Research reveals drug targets for memory enhancement

Bristol-led research has identified specific drug targets within the neural circuits that encode memories, paving the way for significant advances in the treatment of a broad spectrum of brain disorders.

Psychology & Psychiatry

Discovery points to ketamine's long-term antidepressant effects

Building on recent research confirming how ketamine induces rapid antidepressant action, Professor of Pharmacology Lisa Monteggia and her collaborators show how the molecular mechanism of the gene MeCP2 and associated synaptic ...

Medical research

Shootin1a—the missing link underlying learning and memory

In neurons, changes in the size of dendritic spines—small cellular protrusions involved in synaptic transmission—are thought to be a key mechanism underlying learning and memory. However, the specific way in which these ...

Neuroscience

Synaptic transmission: Not a one-way street

Information flows in a well-defined direction in the brain: Chemical and electrical signals are passed from one neuron to the other across the synapse, from the pre-synaptic to the post-synaptic neuron. Now, Peter Jonas and ...

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