Arthritis & Rheumatism

Study identifies key protein that drives rheumatoid arthritis damage

Scientists have identified a protein known as sulfatase-2 that plays a critical role in the damage caused by rheumatoid arthritis. A chronic disease in which the immune system attacks the body's own joint tissues, rheumatoid ...

Medical research

Innate immunity: The final touch for antimicrobial defense

If bacteria enter the body, it often takes just a few minutes for the innate immune system to recognize them as foreign and set the immune defense in motion. Receptors of the immune system that recognize bacterial cell wall ...

Immunology

Uncovering the links between diet, gut health and immunity

A preclinical study from the University of Sydney has found a high-protein diet can change the microbiota of the gut, triggering an immune response. Researchers say the study takes us a step closer to understanding the way ...

Diabetes

Gut microbe peptide implicated in triggering type 1 diabetes

In type 1 diabetes, the body develops immune cells that target pancreatic beta cells, which play a critical role in the production and secretion of insulin. One of the earliest targets of this immune response is a specific ...

Arthritis & Rheumatism

How mitochondrial damage ignites the 'auto-inflammatory fire'

Mitochondria are self-contained organelles (they possess their own mini-chromosome and DNA) residing within cells and are charged with the job of generating the chemical energy needed to fuel functions essential to life and ...

Immunology

In colitis patients, skin conditions may originate in the gut

A new study by UC San Francisco researchers reveals how gut inflammation can disrupt not only the digestive system, but also the skin. It's a tale in which the main players are specialized immune cells and the bacterial communities—called ...

Genetics

Researchers ID gene critical to human immune response

Cedars-Sinai investigators have identified a gene that plays an essential role in the innate human immune system. The gene, NLRP11, helps activate the inflammatory response that tells the body's white blood cells to go on ...

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