Researchers at The University of Texas MD Anderson Cancer Center have discovered how an aggressive form of prostate cancer called double-negative prostate cancer (DNPC) metastasizes by evading the immune system. The investigators ...
Jul 18, 2019
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T-cell receptors (TCRs), found on the surface of antigen specific T-lymphocytes, are incredibly diverse proteins that are programmed to recognize foreign bodies or "antigens," and alert T-cells about their presence in our ...
Jan 19, 2022
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Chimeric antigen receptor (CAR) T cell therapy is a new and in some cases highly effective form of immunotherapy to treat certain types of cancer of the blood and lymph system. This promising treatment comes at a cost, however: ...
Jun 23, 2020
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Researchers at University of California San Diego have found that the most common form of liver cancer—one with a high mortality rate—can be better targeted and treated using an innovative new stem cell-derived therapy, ...
Jul 9, 2024
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Researchers at UT Southwestern Medical Center report the identification of a new cellular source for an important disease-fighting protein used in the body's earliest response to infection.
Jul 10, 2013
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Scientific advancements have often been held back by the need for high volumes of data, which can be costly, time-consuming, and sometimes difficult to collect. But there may be a solution to this problem when investigating ...
Jul 20, 2022
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T cells are the key immune system component involved in killing cancer. Tumors produce signals that turn off these T cells, partially by forcing them to progressively differentiate (mature) into a hypofunctional state known ...
Nov 15, 2023
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Abecma (idecabtagene vicleucel), a chimeric antigen receptor (CAR) T-cell therapy, was approved by the U.S. Food and Drug Administration for the treatment of multiple myeloma, the agency announced Saturday.
Mar 31, 2021
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CAR-T cell therapy is a last hope for many patients with blood, bone marrow or lymph gland cancer when other treatments such as chemotherapy are unsuccessful. A limiting factor of this otherwise very effective and safe therapy ...
Nov 6, 2023
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Johns Hopkins scientists have used a form of artificial intelligence to create a map that compares types of cellular receptors, the chemical "antennas" on the surface of immune system T-cells. Their experiments with lab-grown ...
Jan 8, 2018
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