Immune cells capable of attacking healthy organs "see" their targets differently than do protective immune cells that attack viruses, according to work published online this week in the Journal of Experimental Medicine.
Feb 6, 2012
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Patients with Guillain-Barré syndrome (GBS) face a rare and heterogeneous disorder of the peripheral nervous system that is often triggered by preceding infections and causes severe muscle weakness. In Europe and the U.S., ...
Jan 19, 2024
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Immunotherapy unleashes the power of the immune system to fight cancer. However, for some patients, immunotherapy doesn't work, and new research may help explain why. When immune cells called T lymphocytes infiltrate malignant ...
May 9, 2022
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Most deaths caused by the malarial parasite Plasmodium falciparum result from the onset of cerebral malaria. This severe neurological condition arises when parasites accumulate within the brain vasculature. Numerous studies ...
Sep 11, 2013
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White blood cells known as B cells have been shown to be effective for predicting which cancer patients will respond to immune checkpoint blockade (ICB) therapy, according to a study at The University of Texas MD Anderson ...
Mar 25, 2019
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Just as a uniform helps distinguish a soldier from a police officer, scientists use proteins that immune cells wear on their surfaces to determine their job in the body. T cells, for example, that display the CD8 protein ...
Apr 26, 2013
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Even as the first vaccines for SARS-CoV-2, the virus that causes COVID-19, are being distributed, scientists and clinicians around the world have remained steadfast in their efforts to better understand how the human immune ...
Jan 27, 2021
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When mice lacking key adaptive immune cells were infected with SARS-CoV-2 virus, even though they are not able to clear the virus, they developed no symptoms, revealing that the body's own inflammatory immune response to ...
Jan 11, 2024
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Targeted therapies specifically attach to and hinder cancer-causing proteins, but cancer cells can quickly evolve to thwart their action. A second drug class, immunotherapies, harnesses the immune system to attack cancer ...
Oct 17, 2022
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Among available immunotherapies, the use of CAR T cells is proving extremely effective against certain blood cancers, but only in half of patients. A main reason for this is the premature dysfunction of these immune cells, ...
Sep 20, 2023
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