Tau is a key brain protein involved in Alzheimer's disease and other brain diseases. Aggregates of Tau known as "neurofibrillary tangles" have been associated with nerve cell death and cognitive decline.
Jan 31, 2017
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Under ordinary circumstances, the protein tau contributes to the normal, healthy functioning of brain neurons. In some people, though, it collects into toxic tangles that damage brain cells. Such tangles are a hallmark of ...
Jan 25, 2017
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Alzheimer's disease affects more than 35 million people, a number that is expected to increase in the coming years. Currently, Alzheimer's diagnoses rely on clinical neuropathologic assessment of amyloid-β (Aβ) peptide ...
Dec 7, 2016
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Tangled up brain fibrils made up of a rogue protein known as tau are the hallmark of Alzheimer's disease (AD) that likely hold the key to treatments, making them of great interest to researchers. Mimicking the formation and ...
Nov 16, 2016
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A recently-recognized pathologic protein in the brain may play a larger role in the development of clinical Alzheimer's disease dementia than previously recognized, according to a study by researchers at Rush University Medical ...
Sep 30, 2016
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For decades, scientists have known that people with two copies of a gene called apolipoprotein E4 (ApoE4) are much more likely to have Alzheimer's disease at age 65 than the rest of the population. Now, researchers at the ...
Aug 17, 2016
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The accumulation of β-Amyloid (Αβ) and tau proteins in the brain is hallmark pathology for Alzheimer disease. Recently developed positron emission tomography (PET) tracers, including [18F]-AV-1451, bind to tau in neurofibrillary ...
Jul 25, 2016
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Using a novel, newly developed mouse model that mimics the development of Alzheimer's disease in humans, Johns Hopkins researchers say they have been able to determine that a one-two punch of major biological "insults" must ...
Jul 4, 2016
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Writing in the April 11 issue of the Journal of Clinical Investigation, researchers at University of California, San Diego School of Medicine say abnormalities in a protein that helps transport and sort materials inside cells ...
Apr 11, 2016
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Newly published research led by the Yale School of Public Health demonstrates that individuals who hold negative beliefs about aging are more likely to have brain changes associated with Alzheimer's disease.
Dec 7, 2015
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