An international team of researchers from the University of Massachusetts Medical School, the University of Bonn and the Center for Advanced European Studies and Research in Germany have shown that a well-known immune and ...
Dec 19, 2012
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Tau is a protein that helps stabilize the internal skeleton of nerve cells (neurons) in the brain. Groups of toxic tau protein, termed tau oligomers, drive disease progression and memory loss in Alzheimer's disease (AD). ...
Feb 22, 2021
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Over a hundred years after they were first identified, two ominous signposts of Alzheimer's disease (AD) remain central topics of research—both formed by sticky accumulations of protein in the brain. Amyloid beta solidifies ...
Aug 14, 2019
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Researchers at the MRC Laboratory of Molecular Biology (LMB) have, for the first time, revealed the atomic structures of one of the two types of the abnormal filaments which lead to Alzheimer's disease. Understanding the ...
Jul 6, 2017
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In the wake of recent disappointments over clinical trials targeting amyloid plaque build-up in Alzheimer's disease, researchers are focusing more attention on misfolded tau protein, another culprit in brain diseases that ...
Dec 18, 2019
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Clinical studies have demonstrated a strong association between Alzheimer's disease (AD) and delirium. A change to the Tau protein, which can lead to the formation of tangles in brain, is one of the hallmarks of AD pathology, ...
Jul 8, 2022
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An international research team, co-led by scientists at Mayo Clinic's campus in Florida, have discovered three potential susceptibility genes for development of progressive supranuclear palsy (PSP), a rare neurodegenerative ...
Jun 19, 2011
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Neurons that regularly remodel are more prone to Alzheimer's disease and die when that remodeling goes awry, a new study suggests. The work is the first to track the progression of Alzheimer's at the genetic and molecular ...
Jun 29, 2020
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Researchers at the University of Alabama at Birmingham are on the track of a gene that might play a role in the development of Alzheimer's disease. The research team is studying a gene called BIN1, which was first linked ...
Sep 4, 2020
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Massachusetts General Hospital (MGH) investigators have discovered a mechanism behind the spread of neurofibrillary tangles - one of the two hallmarks of Alzheimer's disease - through the brains of affected individuals. In ...
Oct 26, 2015
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