Stem cells from the human stomach can be converted into cells that secrete insulin in response to rising blood sugar levels, offering a promising approach to treating diabetes, according to a preclinical study from researchers ...
May 25, 2023
0
30
Our bodies make blood in a specialized niche—a "nursery" within our bone marrow that nurtures blood stem cells so they can replicate and make different kinds of blood cells. The lab of Leonard Zon, MD, has even shown how ...
May 24, 2023
0
93
A new Nature Immunology study led by University of Pittsburgh and National Institutes of Health researchers sheds light on how a rare type of helper T cell, called Th9, can drive allergic disease, suggesting new precision ...
May 3, 2023
0
41
Mutating cells can prevent the spread of cancer by flipping themselves into a state of reduced activity called senescence. Cancer genes, however, can retaliate by reviving those cells so they can replicate again.
Apr 21, 2023
0
25
Women who experienced high stress during childhood and adolescence may have increased risk for inflammation during pregnancy, according to a study by researchers with the Eunice Kennedy Shriver National Institute of Child ...
Mar 29, 2023
0
34
A team led by Van Andel Institute and Max Planck Institute of Immunobiology and Epigenetics scientists has identified two distinct subtypes of insulin-producing beta cells, or ß cells, each with crucial characteristics that ...
Mar 28, 2023
0
104
Cancer-associated genes called oncogenes are well known to stimulate cell growth and division—causing tumors to balloon and spread. But now, researchers at the Stanford School of Medicine and Sarafan ChEM-H have found that ...
Mar 24, 2023
0
83
Genes long known to control the formation of bones before birth also control bone healing later in life, a new study found.
Mar 20, 2023
0
15
Custom-made to attack cancer cells, CAR T-cell therapies have opened a new era in the treatment of human cancers, particularly, in hematologic malignancies. All too often, however, they display a frustrating trait inherited ...
Mar 20, 2023
0
162
The enzyme TBK1 is an important component of the innate immune system that plays a critical role in the defense against viruses. Upon mutation-induced loss of TBK1 function, patients show an increased susceptibility to viral ...
Mar 10, 2023
0
24
In the field of molecular biology, a transcription factor (sometimes called a sequence-specific DNA binding factor) is a protein that binds to specific DNA sequences and thereby controls the transfer (or transcription) of genetic information from DNA to mRNA. Transcription factors perform this function alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme which performs the transcription of genetic information from DNA to RNA) to specific genes.
A defining feature of transcription factors is that they contain one or more DNA binding domains (DBDs) which attach to specific sequences of DNA adjacent to the genes that they regulate. Additional proteins such as coactivators, chromatin remodelers, histone acetylases, deacetylases, kinases, and methylases, while also playing crucial roles in gene regulation, lack DNA binding domains, and therefore are not classified as transcription factors.
This text uses material from Wikipedia, licensed under CC BY-SA
