Oncology & Cancer

Chimeras offer a new way to study childhood cancers in mice

In a new paper published March 5 in the journal Cell Stem Cell, researchers in Whitehead Institute Member Rudolph Jaenisch's lab introduce a new way to model human neuroblastoma tumors in mice using chimeras—in this case, ...

Oncology & Cancer

Fibroblasts involved in healing spur tumor growth in cancer

The connective tissue cells known as fibroblasts are vitally important for our recovery from injury. Sensing tissue damage, they gravitate to the site of a wound, instigating an inflammatory response that mends damaged tissue.

Medical research

New drug target discovered for the lung disease PAH

Scientists have identified a molecular pathway that contributes to the development of pulmonary arterial hypertension (PAH), a severe, often fatal condition that has no cure.

Medical research

Gut microbes may affect the course of ALS

Researchers at the Weizmann Institute of Science have shown in mice that intestinal microbes, collectively termed the gut microbiome, may affect the course of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's ...

Diseases, Conditions, Syndromes

New skin test detects prion infection before symptoms appear

Prions can infect both humans and animals, causing Creutzfeldt-Jakob disease (CJD) in humans, mad cow disease in cattle, and chronic wasting disease in elk and deer. The infectious, misfolded protein particles often go undetected ...

Neuroscience

The brain clock that keeps memories ticking

Just as members of an orchestra need a conductor to stay on tempo, neurons in the brain need well-timed waves of activity to organize memories across time. In the hippocampus—the brain's memory center—temporal ordering ...

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