Neuroscience

Lack of CLOCK protein appears key in severe epilepsy forms

A new study in Neuron focuses on the role that a lack of the protein "CLOCK" plays in several forms of epilepsy. The study provides evidence that excessive excitation of specific brain cells may be due to a lack of CLOCK ...

Medical research

Impaired recycling of mitochondria in autism?

Tuberous sclerosis complex (TSC), a genetic disorder that causes autism in about half of those affected, could stem from a defect in a basic system cells use to recycle their mitochondria, report scientists at Boston Children's ...

Medications

Metformin trial dramatically reduces seizures in tuberous sclerosis

A team of researchers led by UCL Great Ormond Street Institute of Child Health (ICH) and Great Ormond Street Hospital (GOSH) has found that metformin—a drug commonly used to treat Type 2 diabetes—can successfully reduce ...

Neuroscience

New drug pathway linked with tuberous sclerosis

Tuberous sclerosis complex (TSC) is a neurological disorder causing non-cancerous tumors, called cortical tubers, to grow throughout the brain and body, as well as other conditions like epilepsy and autism. While medications ...

Genetics

Two independent mechanisms are involved in tuberous sclerosis

The current idea about how tuberous sclerosis occurs places mTORC1, a protein complex that regulates cell metabolism, as the major driving force behind the disease. But according to a new study published in the Proceedings ...

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