Oncology & Cancer
Researchers see helpful protein causing cancer
Washington State University researchers have determined how a protein that helps cells fight viruses can also cause genetic mutations that lead to cancer.
Feb 9, 2016
0
48
Page 30 - News tagged with tumor mutations
Oncology & Cancer
Single-lesion biopsy may be insufficient to choose therapy targeting resistance mutations
When metastatic tumors driven by drug-targetable genetic mutations become resistant to a targeted therapy drug, the usual practice is to biopsy a single metastatic lesion to test for new mutations that can guide the selection ...
Feb 5, 2016
0
23
Oncology & Cancer
Rare Diseases: De novo mutation leading to Fanconi Anemia identified
An international team of researchers has established the cause of rare syndrome consistent with Fanconi Anemia: a de novo mutation in a so called RAD51 gene, which is responsible for repairing damages in the DNA. Fanconi ...
Dec 22, 2015
0
0
Oncology & Cancer
Researchers discover genetic cause of second-most common kidney cancer in children
The genetic basis of clear cell sarcoma of the kidney (CCSK), a high-risk childhood cancer known for metastasizing to bone and brain, has remained a mystery since the cancer was first described in the 1970s. A team of researchers ...
Nov 19, 2015
0
37
Oncology & Cancer
Enormous genetic variation may shield tumors from treatment
The most rigorous genetic sequencing ever carried out on a single tumor reveals far greater genetic diversity among cancer cells than anticipated. Researchers from the University of Chicago and the Beijing Institute of Genomics ...
Nov 9, 2015
0
39
Oncology & Cancer
Mutant-IDH1 inhibitor AG-120 shows early promise against solid tumors with IDH1 mutations
The investigational anticancer therapeutic AG-120, which targets mutant IDH1 protein, was well tolerated and showed signs of clinical activity in patients who had advanced solid tumors positive for mutant IDH1, according ...
Nov 9, 2015
0
9
Oncology & Cancer
Investigational AKT inhibitor AZD5363 is active against multiple tumor types with AKT1 E17K mutations
Treatment with the investigational pan-AKT inhibitor AZD5363 led to tumor regression in patients with a variety of types of solid tumors positive for the AKT1 E17K genetic mutation, according to data from a phase I clinical ...
Nov 9, 2015
0
3
Oncology & Cancer
Targeted treatment produces rapid shrinkage of recurrent, BRAF-mutant brain tumor
A team led by Massachusetts General Hospital (MGH) investigators has reported the first successful use of a targeted therapy drug to treat a patient with a debilitating, recurrent brain tumor. In a paper published online ...
Nov 6, 2015
0
68
Oncology & Cancer
Researchers use gut bacteria composition to genetically classify colorectal tumors
By analyzing the types of gut bacteria present around colorectal tumors, researchers have found a way to predict key genetic mutations in the tumors themselves, a method that could eventually inform the development of colorectal ...
Oct 9, 2015
0
11
Oncology & Cancer
CanDL database shines light on clinically important cancer gene mutations
Many clinical trials use genome sequencing to learn which gene mutations are present in a patient's tumor cells. The question is important because targeting the right mutations with the right drugs can stop cancer in its ...
Aug 27, 2015
0
7
