Functional loss of ARID1a, a frequently mutated tumor suppressor gene, causes deficiencies in normal DNA repair and may sensitize tumors to immune checkpoint blockade therapies, according to researchers from The University ...
May 7, 2018
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A team of researchers affiliated with several institutions in the U.K. and one in the U.S. has developed a way to use artificial intelligence to predict how cancer might change and spread in patients. The results are published ...
An existing drug may help some patients with non-small-cell lung cancer (NSCLC) whose tumors have become resistant to chemotherapy, finds a study from Boston Children's Hospital and the Dana-Farber Cancer Institute (DFCI). ...
Jan 28, 2015
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Inside cells DNA is tightly wrapped around proteins and packed in a complex, 3-D structure called chromatin. Chromatin not only protects genetic material from damage, but also organizes the entire genome by regulating the ...
Jan 29, 2019
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Scientists at Joslin Diabetes Center in Boston have uncovered important molecular and genetic keys to the development of soft-tissue sarcomas in skeletal muscle, giving researchers and clinicians additional targets to stop ...
Nov 30, 2011
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CU Boulder researchers have discovered a protein's crucial role in helping breast and ovarian tumors survive and thrive and have found that suppressing that protein kills cancer cells without harming healthy ones.
Apr 13, 2023
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Cancer spreads throughout the human body in cunning, almost militaristic, ways. For example, it can manipulate our genetic make-up, take over specific cell-to-cell signaling processes, and mutate key enzymes to promote tumor ...
Jul 3, 2023
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St. Jude Children's Research Hospital scientists have evidence that children with acute lymphoblastic leukemia mount a robust immune response to their cancer. The findings, which appear today in the journal Science Translational ...
Jun 26, 2019
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A protective mutation found in most cells in the human esophagus reduces tumor growth in mice, potentially highlighting new ways to prevent or treat cancer in similar tissues.
Jan 20, 2023
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Tumor suppressor genes protect cells from malignant transformation. If they are turned off as a result of chemical modifications in DNA, called epigenetic labels, this contributes to the development of cancer. As opposed ...
Jun 12, 2017
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