T cells targeting p53 hotspot mutations can be harvested from peripheral blood of patients with metastatic solid epithelial cancers, according to results published in Clinical Cancer Research, a journal of the American Association ...
Jan 29, 2020
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A new study led by researchers at The Ohio State University Comprehensive Cancer Center—Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC—James) shows how resistance to a promising targeted ...
Jan 14, 2020
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Like security screening to make sure nothing harmful makes its way into a crowded area, cells in the human body use checkpoints to control their growth and prevent harmful mutations from making their way into new cell populations ...
Jan 9, 2020
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For older patients with acute myeloid leukemia (AML), the prospects for success of a stem cell transplant can often be predicted based on the particular set of genetic mutations within the tumor cells, investigators at Dana-Farber ...
Dec 7, 2019
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Sarcomas—cancers that arise from transformed mesenchymal cells (a type of connective tissue)—are quite deadly. Gastrointestinal stromal tumors (GISTs) are the most common human sarcoma and are initiated by activating ...
Oct 24, 2019
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As tumor cells multiply, they often spawn tens of thousands of genetic mutations. Figuring out which ones are the most promising to target with immunotherapy is like finding a few needles in a haystack. Now a new model developed ...
Oct 9, 2019
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A recent study in The FASEB Journal identifies a new mechanism of pancreatic tumors' resistance to chemotherapeutic treatment. The mechanism involves the loss of function of promyelocytic leukemia protein (PML), which operates ...
Sep 26, 2019
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Oxford University epidemiologist Richard Peto was puzzled by a paradox: If cancer is a function of individual cells going haywire, wouldn't an organism with a lot more cells, say a whale, have a greater chance of getting ...
Aug 28, 2019
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Scientists have shown exactly how mutations in two different genes coordinate to drive the development of malignant lung tumors, according to a new report in the open-access journal eLife.
Aug 27, 2019
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Are you enjoying the summer? Out grilling, swimming and hiking? Beware: those sunny days may come with a cost.
Jul 31, 2019
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