Investigators at the Ted Rogers Centre for Heart Research have discovered a surprising new role for tumor necrosis factor (TNF): namely, that it is a major regulator of small blood vessel function, the key determinant of ...
Apr 6, 2017
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Twenty years ago, tumor necrosis factor (TNF) seemed a promising target in the treatment of brain diseases like multiple sclerosis or Alzheimer's Disease. But clinical trials produced disappointing results. Now University ...
Oct 10, 2016
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Periodontitis is a risk factor for heart disease. Now a team of researchers has shown that a periodontal pathogen causes changes in gene expression that boost inflammation and atherosclerosis in aortic smooth muscle cells. ...
Sep 11, 2015
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Cells lining the intestinal tract form a critical barrier, protecting our bodies from the billions of bacteria living in the gut. Breaches in this barrier are driven largely by a single signaling molecule called tumor necrosis ...
Feb 16, 2015
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Cornell biomedical engineers have discovered a new way to destroy metastasizing cancer cells traveling through the bloodstream – lethal invaders that are linked to almost all cancer deaths – by hitching cancer-killing ...
Jan 6, 2014
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(Medical Xpress)—Two new studies suggest that events that transpire during the life of a mouse may have an impact on memory mechanics in their offspring. Both studies were conducted by teams in the U.S. and both have had ...
Vedolizumab, a new intravenous antibody medication, has shown positive results for treating both Crohn's disease and ulcerative colitis, according to researchers at the University of California San Diego, School of Medicine. ...
Aug 21, 2013
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(Medical Xpress)—A previously unknown function of a family of enzymes familiar to biologists may contribute to scientists' understanding of signaling molecules involved in the body's immune response and could help in the ...
Apr 12, 2013
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Tumor necrosis factor—normally an infection-fighting substance produced by the body—can actually heighten susceptibility to tuberculosis if its levels are too high. University of Washington TB researchers unravel this ...
Apr 11, 2013
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Researchers at Hospital for Special Surgery have identified a potential new target for drugs to treat patients with rheumatoid arthritis (RA), a protein known as IRHOM2. The finding could provide an effective and potentially ...
Jan 25, 2013
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