Oncology & Cancer
Targeting ras with protein engineering
A review paper titled "Targeting Ras with protein engineering" has been published in Oncotarget.
Nov 27, 2023
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News tagged with tumor suppressor gene
Medications
New cancer drug shows promise targeting genetic weakness in tumors
Imagine the body's cells are well-behaved students in the classroom. The "teachers" are tumor suppressor genes, and they make sure cells follow the rules. But when tumor suppressor genes are away, cells may go astray.
Nov 1, 2023
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Oncology & Cancer
Host genetics helps explain childhood cancer survivors' mortality risk from second cancers
The population of childhood cancer survivors in the U.S. is increasing, with an overall childhood cancer survival rate greater than 85% five years after diagnosis. However, survivors can still be at increased risk of various ...
Oct 2, 2023
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Oncology & Cancer
DPP4 inhibitors for target therapy resistance in renal cell carcinoma
A new editorial paper titled "Potential repurposing of DPP4 inhibitors for target therapy resistance in renal cell carcinoma" has been published in Oncotarget.
Sep 20, 2023
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Oncology & Cancer
Tethering of shattered chromosomal fragments paves way for new cancer therapies
Healthy cells work hard to maintain the integrity of our DNA, but occasionally, a chromosome can get separated from the others and break apart during cell division. The tiny fragments of DNA then get reassembled in random ...
Jun 15, 2023
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Oncology & Cancer
Gene-editing technique could speed up study of cancer mutations
Genomic studies of cancer patients have revealed thousands of mutations linked to tumor development. However, for the vast majority of those mutations, researchers are unsure of how they contribute to cancer because there's ...
May 11, 2023
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Oncology & Cancer
Mutations in three key genes associated with poor outcomes in lung cancer patients treated with KRAS G12C inhibitors
A new study led by researchers at The University of Texas MD Anderson Cancer Center has discovered that co-occurring mutations in three tumor suppressor genes—KEAP1, SMARCA4 and CDKN2A—are linked with poor clinical outcomes ...
Apr 17, 2023
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Oncology & Cancer
Cancer researchers identify protein with novel anti-tumoral activities
Understanding how cancer develops is critical for designing effective, personalized cancer therapies. Researchers have known for years that cancer begins with mutations in certain types of genes. One of these types of cancer ...
Apr 6, 2023
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Oncology & Cancer
Researchers ID biomarkers of response to immunotherapy for kidney cancer
The number of immune cells in and around kidney tumors, the amount of dead cancer tissue, and mutations to a tumor suppressor gene called PBRM1 form a biomarker signature that can predict—before treatment begins—how well ...
Apr 6, 2023
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Medications
New findings support novel combination treatment for head and neck cancers
Human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) and lung cancer can have disruptive mutations in TP53 and/or CDKN2A tumor suppressor genes, which are associated with poor patient survival.
Apr 5, 2023
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Tumor suppressor gene
A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes.
This text uses material from Wikipedia, licensed under CC BY-SA
