Genetics

Regulatory RNA essential to DNA damage response

Stanford researchers have found that a tumor suppressor known as p53 is stabilized by a regulatory RNA molecule called DINO. The interaction helps a cell respond to DNA damage and may play a role in cancer development and ...

Oncology & Cancer

How a metabolic pathway promotes breast cancer metastasis

A metabolic pathway that is up-regulated in certain breast cancers promotes the disease's progression by activating a cell signaling protein called Arf6, according to a paper published in the Journal of Cell Biology. The ...

Oncology & Cancer

Causal link between aneuploidy and cancer

One of the key unresolved question in cancer is whether aneuploidy, as defined by the presence of gain or loss of chromosomes, is the cause or the consequence of cancer development. Since the observations by Boveri and Von ...

Oncology & Cancer

Pactamycin analogs offer new, gentler approach to cancer treatment

Researchers at Oregon State University are pursuing a new concept in treatment of epithelial cancer, especially head and neck cancer, by using two promising "analogs" of an old compound that was once studied as a potent anti-tumor ...

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