Mutations in the ARID1A gene are present in more than 50% of ovarian clear cell carcinomas (OCCC), for which effective treatments are lacking. Scientists at The Wistar Institute discovered that loss of ARID1A function enhances ...
Sep 21, 2021
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Research led by UNC School of Medicine student Wesley Stepp, Ph.D., shows how more detailed genetic testing of head and neck tumors could lead to more personalized treatments for patients.
Apr 26, 2018
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A team of scientists, comprising researchers from the Institute of Molecular and Cell Biology (IMCB), a research institute under the Agency for Science, Technology and Research (A*STAR), Singapore, and the VIB Laboratory ...
Dec 16, 2015
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A recent study in The FASEB Journal identifies a new mechanism of pancreatic tumors' resistance to chemotherapeutic treatment. The mechanism involves the loss of function of promyelocytic leukemia protein (PML), which operates ...
Sep 26, 2019
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Researchers have revealed the mechanism of a drug shown to be effective in treating certain types of cancer, which targets a protein modification silencing the expression of multiple tumor suppressor genes. They also demonstrated ...
Feb 21, 2024
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Mount Sinai researchers have broken new ground in the understanding of the MDM2 gene—which is often overexpressed in cancer—finding that when it acts with a specific protein, it can lead to cancer cell death. The study ...
May 1, 2019
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With approximately 50 million scientific papers available in public databases– and a new one publishing nearly every 30 seconds – scientists cannot know about every relevant study when they are deciding where to take ...
Aug 25, 2014
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According to the American Cancer Society, nearly 40,000 women in the United States will succumb to breast cancer this year. Most of these women will die not from the primary tumor but rather tumor recurrence – the reappearance ...
Jun 13, 2013
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The p53 tumor suppressor protein is encoded by TP53, the most frequently mutated gene in cancer. A review article published in Nature Reviews Clinical Oncology by Professor Klas G Wiman and colleagues at the Department of ...
Dec 19, 2023
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November is Lung Cancer Awareness Month, highlighting the number one cause of cancer-related death in North America. While prognosis for the most common form, adenocarcinoma, has remained poor, new research has shown a link ...
Nov 3, 2015
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