Among patients with previously treated HER2-positive metastatic breast cancer, those who received pyrotinib plus capecitabine had longer overall survival than those who received lapatinib (Tykerb) plus capecitabine, according ...
Dec 8, 2021
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A new study from the University of Southern California could pave the way for improving personalised lung cancer care and treatment.The research used mathematical modelling to examine if there was a link between the molecular ...
Jul 12, 2017
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A*STAR researchers have clarified the role of one particular regulatory protein in controlling the development of plasma cells, opening up several new avenues toward clinical applications.
Apr 30, 2015
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Aberrant regulation of cell growth pathways is required for normal cells to become cancerous, and in many types of cancer, cell growth is driven by a group of enzymes known as receptor tyrosine kinases (RTKs). The RTK epidermal ...
Aug 13, 2012
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Tyrosine kinases are enzymes that play central roles in signaling by cytokines involved in the pathogenesis of autoimmune diseases, including lupus. A recent phase 2 clinical trial published in Arthritis & Rheumatology has ...
Nov 12, 2022
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Epidermal growth factor receptor (EGFR) mutations found in the circulating free tumor DNA (ctDNA) from the plasma of advanced non-small cell lung cancer (NSCLC) patients correlates well with the EGFR mutations from patient-matched ...
Aug 22, 2014
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Patients with chronic myeloid leukemia can be treated with tyrosine kinase inhibitors. While these effective drugs lead to deep remission and prolonged survival, primitive leukemia stem cells resist elimination during the ...
Jun 11, 2019
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Some cancer drugs used to treat patients with leukemia may also help stop the Ebola virus and give the body time to control the infection before it turns deadly, US researchers said on Wednesday.
Feb 29, 2012
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Two clinical studies published in the New England Journal of Medicine with an accompanying editorial suggest that the novel agent ibrutinib shows real potential as a safe, effective, targeted treatment for adults with chronic ...
Jun 19, 2013
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A new editorial paper titled "Systemic treatment for brain metastasis in HER2- positive advanced breast cancer: what have we learned so far?" has been published in Oncotarget.
Sep 13, 2023
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