A key protein, which may be activated to protect nerve cells from damage during heart failure or epileptic seizure, has been found to regulate the transfer of information between nerve cells in the brain. The discovery, made ...
Apr 22, 2012
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Tumor protein P53 (TP53) plays an important role in suppressing the growth of tumors. Mutations in the gene for TP53 can have a disastrous effect, hampering the body's ability to fight tumors and even encouraging their growth. ...
May 30, 2024
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A gene regulating the F-Box and WD Repeat Domain Containing 7 (FBXW7) protein is frequently mutated or deleted in various types of human cancer, including gynecological cancers. Such FBXW7 mutations have been associated with ...
May 18, 2023
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A recent study published in Oncogene and led by Dr. Sun Yu's group at Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences revealed the roles and functional mechanisms of senescence-associated ...
Oct 25, 2022
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More-effective therapies are greatly needed for children with the high-risk blood cancer T-cell acute lymphoblastic leukemia (T-ALL). St. Jude Children's Research Hospital scientists have leveraged the latest chemical technology ...
Aug 24, 2022
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Our bodies contain a special protein tag that plays a role in how cells recover from specific threats to their survival, according to new research I co-authored. Understanding how this process works may be key to future treatments ...
Jun 25, 2021
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Researchers at the University of Copenhagen's Department of Nutrition, Exercise and Sports have demonstrated that physical activity prompts a clean-up of muscles as the protein ubiquitin tags onto worn-out proteins, causing ...
May 28, 2020
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Squamous cell carcinoma is a very unusual type of cancer. It occurs in many tissues—for example in the lungs, esophagus, pancreas, throat and pharynx, and on the skin. Due to the many mutations in this type of cancer, treatment ...
Mar 10, 2020
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Researchers from VIB-UGent Center for Medical Biotechnology, University of Iowa (USA) and other collaborators, developed a novel approach to better understand a basic defense mechanism of our immune system. Central is ISG15, ...
Nov 26, 2019
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Traditional medicines mostly function as inhibitors, attacking the disease-relevant proteins that cause cancer, by binding to their accessible pockets. Following this strategy, only ~20% of all proteins are chemically addressable, ...
Aug 23, 2019
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