Gastroenterology

War in the gut: How human microbiota resist the cholera bacterium

Cholera is still an enormous public health problem. There have been seven major pandemics of the acute diarrheal disease in the last 200 years. According to the WHO, cholera still kills up to 143,000 people each year and ...

Diseases, Conditions, Syndromes

Potential cholera vaccine target discovered

Findings from a team led by investigators at Massachusetts General Hospital (MGH), reported in the online journal mBio, may help scientists develop a more effective vaccine for cholera, a bacterial disease that causes severe ...

Diseases, Conditions, Syndromes

Cause of 1990s Argentina cholera epidemic uncovered

The evolution of epidemic and endemic strains of the cholera-causing bacterium Vibrio cholerae in Argentina has been mapped in detail by researchers at the Wellcome Sanger Institute, the London School of Hygiene and Tropical ...

Diseases, Conditions, Syndromes

How cholera bacteria make people so sick

The enormous adaptability of the cholera bacterium explains why it is able to claim so many victims. Professor Ariane Briegel from the Leiden Institute of Biology has now discovered that this adaptability is due to rapid ...

Diseases, Conditions, Syndromes

Fast-acting cholera vaccine could curb outbreaks

A tricked-out cholera vaccine starts protecting against the deadly disease within a day, experiments in rabbits suggest. The rapid protection offered by this designer vaccine may one day limit the spread of cholera outbreaks, ...

Medical research

Turning the tables on the cholera pathogen

Recent cholera outbreaks in regions that are ravaged by war, struck by natural disasters, or simply lack basic sanitation, such as Yemen or Haiti, are making the development of new and more effective interventions a near-term ...

Diseases, Conditions, Syndromes

Risk of cholera epidemics estimated with new rule-book

Cholera has repeatedly traveled out of Asia to cause epidemics in Africa and Latin America, an international research team has found. Researchers at the Wellcome Trust Sanger Institute, Institut Pasteur in France, and collaborators ...

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