Diseases, Conditions, Syndromes

How the dengue virus replicates in infected cells

The nonstructural protein 1 (NS1) of the dengue virus interacts with another viral protein called NS4A-2K-4B to enable viral replication, according to a study published May 9 in the open-access journal PLOS Pathogens by Ralf ...

Diseases, Conditions, Syndromes

Team tackles equine encephalitis viruses

Viruses without a preventative vaccine or treatment option pose a looming threat. But for viruses in this category that have already been weaponized and are recognized as human biothreats by the Centers for Disease Control ...

Cancer

Engineering a cancer-fighting virus

Hokkaido University researchers have engineered a virus that selectively targets and kills cancer cells. The virus, called dl355, has an even stronger anticancer effect than another engineered virus currently used in clinical ...

Diseases, Conditions, Syndromes

Cellular protein a target for Zika control

A cellular protein that interacts with invading viruses appears to help enable the infection process of the Zika virus, according to an international team of researchers who suggest this protein could be a key target in developing ...

Diseases, Conditions, Syndromes

RNA processing and antiviral immunity

The RIG-I like receptors (RLRs) are intracellular enzyme sentries that detect viral infection and initiate a first line of antiviral defense. The cellular molecules that activate RLRs in vivo are not clear.

Diseases, Conditions, Syndromes

Reducing unnecessary medication for hepatitis B patients

Not all chronic hepatitis B (HBV) patients require lifelong treatment; but the risks of blindly withdrawing treatment can be severe. However, there's little consensus on which patients can be safely discontinued from treatment, ...

Diseases, Conditions, Syndromes

Exploring new research to combat disease-causing viruses

According to the US Center for Disease Control, the number of worldwide cases of poliomyelitis has decreased from 350,000 in 1988 to 407 in 2013. While the decline has been steady, polio has still not been eradicated. To ...

HIV & AIDS

New compound targets drug-resistant HIV mutants

Antiretroviral therapies have worked wonders suppressing HIV replication and its progression to AIDS, but their effectiveness is deteriorating due to the constant development of drug resistance in the virus. Now Yale researchers ...

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Viral replication

Viral replication is the term used by virologists to describe the formation of biological viruses during the infection process in the target host cells. Viruses must first get into the cell before viral replication can occur. From the perspective of the virus, the purpose of viral replication is to allow production and survival of its kind. By generating abundant copies of its genome and packaging these copies into viruses, the virus is able to continue infecting new hosts. Replication between viruses is greatly varied and depends on the type of genes involved.

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