Diseases, Conditions, Syndromes

Uptick in vector-borne illnesses in US and what it means to you

Illnesses caused by disease-infected ticks, mosquitoes and fleas have tripled in the U.S. in recent years, according to a new report from the Centers for Disease Control and Prevention (CDC). Lyme disease is the most common ...

Immunology

Compound found to trigger innate immunity against viruses

Research from UW Medicine and collaborators indicates that a drug-like molecule can activate innate immunity and induce genes to control infection in a range of RNA viruses, including West Nile, dengue, hepatitis C, influenza ...

Diseases, Conditions, Syndromes

Biologists develop novel antiviral approach to dengue fever

The virus that causes dengue fever infects an estimated 390 million people per year. Infection often leads to symptoms so severe that it was once called "breakbone fever" for the pain it causes, or even death. It's the fastest-growing ...

Diseases, Conditions, Syndromes

Zika retreats widely, but health experts remain concerned

Two years ago, the world was gripped in Zika panic as the mosquito-borne virus infected millions and spread across 80 countries. Officials declared a global health emergency and tourists canceled their tropical vacations. ...

Diseases, Conditions, Syndromes

Viruses in blood lead to digestive problems

While studying viruses best known for infecting the brain, researchers at Washington University School of Medicine in St. Louis stumbled upon clues to a conundrum involving a completely different part of the anatomy: the ...

Diseases, Conditions, Syndromes

Scientists have discovered how mosquitoes develop viral immunity

(Medical Xpress)—Published online in the prestigious Proceedings of the National Academy of Sciences (PNAS), the team from CSIRO's Australian Animal Health Laboratory, in Geelong, have shown Vago, a protein previously identified ...

Diseases, Conditions, Syndromes

Mosquito sample with West Nile virus found in Oakley, Calif.

A mosquito carrying the West Nile virus was discovered in eastern Contra Costa County, Calif., marking the first time this year vector control officials have found such a sample in the county, a spokeswoman said Friday.

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West Nile virus

West Nile virus (or WNV) is a virus of the family Flaviviridae. Part of the Japanese encephalitis (JE) antigenic complex of viruses, it is found in both tropical and temperate regions. It mainly infects birds, but is known to infect humans, horses, dogs, cats, bats, chipmunks, skunks, squirrels, and domestic rabbits. The main route of human infection is through the bite of an infected mosquito.

Image reconstructions and cryoelectron microscopy reveal a 45–50 nm virion covered with a relatively smooth protein surface. This structure is similar to the dengue fever virus; both belong to the genus Flavivirus within the family Flaviviridae. The genetic material of WNV is a positive-sense, single strand of RNA, which is between 11,000 and 12,000 nucleotides long; these genes encode seven non-structural proteins and three structural proteins. The RNA strand is held within a nucleocapsid formed from 12 kDa protein blocks; the capsid is contained within a host-derived membrane altered by two viral glycoproteins.

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