Heart Attack

A shot against heart attacks?

Harvard Stem Cell Institute (HSCI) scientists collaborating with researchers at the University of Pennsylvania have developed a "genome-editing" approach for permanently reducing cholesterol levels in mice ...

Jun 10, 2014
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Scientists explain stress-heart attack link

Scientists said Sunday they may have unravelled how chronic stress leads to heart attack and stroke: triggering overproduction of disease-fighting white blood cells which can be harmful in excess.

Jun 22, 2014
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An attractive solution for heart repair

Stem cell therapy is a promising option for repairing heart tissue damaged by heart attack. However, the main obstacle to cardiac stem cell therapy also happens to be pretty difficult to get around – and ...

Aug 15, 2014
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A new player in lipid metabolism discovered

(Medical Xpress)—Specially engineered mice that lacked a particular gene did not gain weight when fed a typical high-fat, obesity-inducing Western diet. Yet, these mice ate the same amount as their normal ...

Aug 05, 2014
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Why ordinary people become heroes

You've just witnessed a horrific car crash. Your heart is pounding, you're in shock. And the decision you make in the next thirty seconds could be the difference between life and death.

Aug 18, 2014
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Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, results from the interruption of blood supply to a part of the heart, causing heart cells to die. This is most commonly due to occlusion (blockage) of a coronary artery following the rupture of a vulnerable atherosclerotic plaque, which is an unstable collection of lipids (cholesterol and fatty acids) and white blood cells (especially macrophages) in the wall of an artery. The resulting ischemia (restriction in blood supply) and ensuing oxygen shortage, if left untreated for a sufficient period of time, can cause damage or death (infarction) of heart muscle tissue (myocardium).

Classical symptoms of acute myocardial infarction include sudden chest pain (typically radiating to the left arm or left side of the neck), shortness of breath, nausea, vomiting, palpitations, sweating, and anxiety (often described as a sense of impending doom). Women may experience fewer typical symptoms than men, most commonly shortness of breath, weakness, a feeling of indigestion, and fatigue. Approximately one-quarter of all myocardial infarctions are "silent", that is without chest pain or other symptoms.

Among the diagnostic tests available to detect heart muscle damage are an electrocardiogram (ECG), echocardiography, cardiac MRI and various blood tests. The most often used blood markers are the creatine kinase-MB (CK-MB) fraction and the troponin levels. Immediate treatment for suspected acute myocardial infarction includes oxygen, aspirin, and sublingual nitroglycerin.

Most cases of STEMI (ST elevation MI) are treated with thrombolysis or percutaneous coronary intervention (PCI). NSTEMI (non-ST elevation MI) should be managed with medication, although PCI is often performed during hospital admission. In people who have multiple blockages and who are relatively stable, or in a few emergency cases, bypass surgery may be an option, especially in diabetics.

Heart attacks are the leading cause of death for both men and women worldwide. Important risk factors are previous cardiovascular disease, older age, tobacco smoking, high blood levels of certain lipids (triglycerides, low-density lipoprotein) and low levels of high density lipoprotein (HDL), diabetes, high blood pressure, obesity, chronic kidney disease, heart failure, excessive alcohol consumption, the abuse of certain drugs (such as cocaine and methamphetamine), and chronic high stress levels.

This text uses material from Wikipedia licensed under CC BY-SA

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