Lymphoma

New protein-targeting drug shows promise in early trial for patients with high-risk CLL

A new oral targeted drug, idelalisib (GS-1101), has the potential to stave off the need for additional treatments for relapsed or treatment-resistant chronic lymphocytic leukemia (CLL), according to a study led in part by ...

Cancer created May 17, 2013 | popularity not rated yet | comments 0 | with audio podcast

Cancer survivors battle with the blues

Depressed cancer survivors are twice as likely to die prematurely than those who do not suffer from depression, irrespective of the cancer site. That's according to a new study, by Floortje Mols and colleagues, from Tilburg ...

Cancer created May 16, 2013 | popularity 5 / 5 (1) | comments 0

Scheduled imaging studies provide little help detecting relapse of aggressive lymphoma

Imaging scans following treatment for diffuse large B-cell lymphoma do little to help detect a relapse, a Mayo Clinic study has found. The overwhelming majority of patients with this aggressive lymphoma already have symptoms, ...

Cancer created May 16, 2013 | popularity not rated yet | comments 0

Simponi approved for ulcerative colitis

(HealthDay)—Simponi (golimumab) injection has been approved by the U.S. Food and Drug Administration to treat adults with moderate-to-severe ulcerative colitis.

Medications created May 15, 2013 | popularity not rated yet | comments 0

Cancer diagnosis puts people at greater risk for bankruptcy

People diagnosed with cancer are more than two-and-a-half times more likely to declare bankruptcy than those without cancer, according to a new study from Fred Hutchinson Cancer Research Center. Researchers also found that ...

Cancer created May 15, 2013 | popularity not rated yet | comments 0

Researchers discover master regulator that drives majority of lymphoma

A soon-to-be-tested class of drug inhibitors were predicted to help a limited number of patients with B-cell lymphomas with mutations affecting the EZH2 protein. However, a research team, led by investigators at Weill Cornell ...

Cancer created May 13, 2013 | popularity 5 / 5 (2) | comments 0 | with audio podcast

Study identifies possible new acute leukemia marker, treatment target

A study has identified microRNA-155 as a new independent prognostic marker and treatment target in patients with acute myeloid leukemia that has normal-looking chromosomes under the microscope (that is, cytogenetically normal ...

Cancer created May 13, 2013 | popularity not rated yet | comments 0

Scientists show how nerve wiring self-destructs

Many medical issues affect nerves, from injuries in car accidents and side effects of chemotherapy to glaucoma and multiple sclerosis. The common theme in these scenarios is destruction of nerve axons, the ...

Neuroscience created May 09, 2013 | popularity 5 / 5 (1) | comments 0 | with audio podcast

Searching for therapeutic synergy in primary effusion lymphoma

Primary effusion lymphoma (PEL) is a rare, fatal form of aggressive B-cell lymphoma caused by Kaposi's sarcoma-associated herpesvirus (KSHV). The disease most commonly occurs in immunocompromised patients, such as those with ...

Cancer created May 01, 2013 | popularity not rated yet | comments 0

Cancer research often falls short: study

Cancer research tends to involve small studies focused on a single therapy, often falling short of scientific standards seen in other medical investigations, said a study released Monday.

Cancer created Apr 29, 2013 | popularity not rated yet | comments 0

Cancer studies often lack necessary rigor to answer key questions

Fueled in part by an inclination to speed new treatments to patients, research studies for cancer therapies tend to be smaller and less robust than for other diseases.

Cancer created Apr 29, 2013 | popularity 5 / 5 (1) | comments 0

Research spinoff ReXceptor gets license for Alzheimer's treatment

Case Western Reserve's Technology Transfer Office has granted an exclusive license of a novel Alzheimer's Disease (AD) treatment strategy to spinoff company ReXceptor Inc., which plans to initiate early-stage human clinical ...

Alzheimer's disease & dementia created Apr 25, 2013 | popularity 4 / 5 (1) | comments 0

Scientists make brain tumours glow

Stereotactic needle biopsies are an established standard procedure in the diagnostic identification of brain lymphomas and certain brain tumours (gliomas). Up until now the tissue samples removed had to be ...

Cancer created Apr 24, 2013 | popularity 5 / 5 (2) | comments 0

Video reveals cancer cells' Achilles' heel (w/ Video)

(Medical Xpress)—Scientists from the Manchester Collaborative Centre for Inflammation Research (MCCIR) have discovered why a particular cancer drug is so effective at killing cells. Their findings could ...

Cancer created Apr 24, 2013 | popularity 5 / 5 (2) | comments 0 | with audio podcast

Commonly used drug can limit radiation damage to lungs and heart for cancer patients

Unavoidable damage caused to the heart and lungs by radiotherapy treatment of tumours in the chest region can be limited by the administration of an ACE inhibitor, a drug commonly used in the treatment of cardiovascular disease, ...

Cancer created Apr 21, 2013 | popularity not rated yet | comments 0


Lymphoma is a cancer of the lymphocytes, a type of cell that forms part of the immune system. Typically, lymphomas present as a solid tumor of lymphoid cells. Treatment might involve chemotherapy and in some cases radiotherapy and/or bone marrow transplantation, and can be curable depending on the histology, type, and stage of the disease. These malignant cells often originate in lymph nodes, presenting as an enlargement of the node (a tumor). It can also affect other organs in which case it is referred to as extranodal lymphoma. Extranodal sites include the skin, brain, bowels and bone. Lymphomas are closely related to lymphoid leukemias, which also originate in lymphocytes but typically involve only circulating blood and the bone marrow (where blood cells are generated in a process termed haematopoesis) and do not usually form static tumors. There are many types of lymphomas, and in turn, lymphomas are a part of the broad group of diseases called hematological neoplasms.

Thomas Hodgkin published the first description of lymphoma in 1832, specifically of the form named after him, Hodgkin's lymphoma. Since then, many other forms of lymphoma have been described, grouped under several proposed classifications. The 1982 Working formulation classification became very popular. It introduced the category non-Hodgkin lymphoma (NHL), divided into 16 different diseases. However, because these different lymphomas have little in common with each other, the NHL label is of limited usefulness for doctors or patients and is slowly being abandoned. The latest classification by the WHO (2008) lists 70 different forms of lymphoma divided in four broad groups.

Although older classifications referred to histiocytic lymphomas, these are recognized in newer classifications as of B, T or NK cell lineage. True histiocytic malignancies are rare and are classified as sarcomas.

This text uses material from Wikipedia and is available under the GNU Free Documentation License.

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