Lymphoma

Immunotherapy set to revolutionise cancer treatment

Immunotherapy is set to revolutionise the treatment of cancer, according to ESMO President Professor Rolf A. Stahel. His comments come as the ESMO Symposium on Immuno-Oncology 2014 is about to open in Geneva, Switzerland ...

Nov 21, 2014
popularity 3.7 / 5 (9) | comments 0

Side effects of possible anti-cancer strategy discovered

The Malt1 protein is one of the most important control centers in human immune cells and a real all-rounder. Genetic defects in it can lead to the development of lymphatic cancer (lymphoma). A possible therapeutic approach ...

Nov 17, 2014
popularity 5 / 5 (1) | comments 0

Lymphoma is a cancer of the lymphocytes, a type of cell that forms part of the immune system. Typically, lymphomas present as a solid tumor of lymphoid cells. Treatment might involve chemotherapy and in some cases radiotherapy and/or bone marrow transplantation, and can be curable depending on the histology, type, and stage of the disease. These malignant cells often originate in lymph nodes, presenting as an enlargement of the node (a tumor). It can also affect other organs in which case it is referred to as extranodal lymphoma. Extranodal sites include the skin, brain, bowels and bone. Lymphomas are closely related to lymphoid leukemias, which also originate in lymphocytes but typically involve only circulating blood and the bone marrow (where blood cells are generated in a process termed haematopoesis) and do not usually form static tumors. There are many types of lymphomas, and in turn, lymphomas are a part of the broad group of diseases called hematological neoplasms.

Thomas Hodgkin published the first description of lymphoma in 1832, specifically of the form named after him, Hodgkin's lymphoma. Since then, many other forms of lymphoma have been described, grouped under several proposed classifications. The 1982 Working formulation classification became very popular. It introduced the category non-Hodgkin lymphoma (NHL), divided into 16 different diseases. However, because these different lymphomas have little in common with each other, the NHL label is of limited usefulness for doctors or patients and is slowly being abandoned. The latest classification by the WHO (2008) lists 70 different forms of lymphoma divided in four broad groups.

Although older classifications referred to histiocytic lymphomas, these are recognized in newer classifications as of B, T or NK cell lineage. True histiocytic malignancies are rare and are classified as sarcomas.

This text uses material from Wikipedia licensed under CC BY-SA

Latest Spotlight News

How various brain areas interact in decisions

Our decisions can be pictured in the brain. Scientists at the University of Zurich were able to show in a recent study which areas are most active in decision making. Often the so-called prefrontal cortex ...

Study unlocks basis of key immune protein's two-faced role

A Brigham and Women's Hospital-led team has identified a long sought-after partner for a key immune protein, called TIM-3, that helps explain its two-faced role in the immune system—sometimes dampening it, other times stimulating ...

A game changer to boost literacy and maths skills

(Medical Xpress)—Finding the best way to teach reading has been an ongoing challenge for decades, especially for those children in underprivileged areas who fail to learn to read. What is the magic ingredient that will ...

Why do people with autism see faces differently?

The way people with autism spectrum disorder (ASD) gather information - not the judgement process itself - might explain why they gain different perceptions from peoples' faces, according to a new study from ...

How do we make moral judgements?

In a target article published in the current issue of the American Journal of Bioethics (AJOB) Neuroscience, Université de Montréal and IRCM neuroethics experts open the black box of moral intuitions by suggesting a new ...