Medical research

A multiple drug approach to preventing sickle cell crisis

Sickle cell disease is characterized by recurrent episodes of "sickle crisis," also known as vaso-occlusive crisis, in which a patient's red blood cells change shape, clump together and block the flow of blood in small vessels ...

Genetics

Scientists edit gene mutations in inherited form of anemia

A Yale-led research team used a new gene editing strategy to correct mutations that cause thalassemia, a form of anemia. Their gene editing technique provided corrections to the mutations and alleviated the disease in mice, ...

Medical research

Genome engineering paves the way for sickle cell cure

A team of physicians and laboratory scientists has taken a key step toward a cure for sickle cell disease, using CRISPR-Cas9 gene editing to fix the mutated gene responsible for the disease in stem cells from the blood of ...

Medical research

New approach could make bone marrow transplants safer

Harvard Stem Cell Institute (HSCI) scientists have taken the first steps toward developing a treatment that would make bone marrow - blood stem cell - transplantation safer and, as a result, more widely available to the millions ...

Pediatrics

New book identifies 50 studies every pediatrician should know

Now that she is a first-time mother of a six-month-old boy, Ashaunta Anderson, MD, MPH, is especially happy to be one of five authors of the just published book, "50 Studies Every Pediatrician Should Know" (Oxford University ...

Genetics

Storing babies' blood samples pits privacy versus science

Two-day-old Ellie Bailey squirms in a hospital bassinet and cries as her tiny left heel is squeezed and then pricked with a needle to draw a blood sample. An Indianapolis hospital technician quickly saturates six circles ...

Genetics

Scientists discover important genetic source of human diversity

Researchers at Harvard Medical School and Dana-Farber Cancer Institute report that humans have a surprisingly high number of genes in which one of two copies has been randomly silenced. They suggest that the phenomenon is ...

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