Journal of Clinical Investigation

Oncology & Cancer

Epigenetic 'priming' boosts ovarian cancer immunotherapy

An epigenetic inhibitor can boost immune system activity in patients with ovarian cancer, making them more suitable for treatment with immunotherapy, according to a Northwestern Medicine study published in the Journal of ...

Medical research

Scientists decipher the danger of gummy phlegm in severe COVID-19

Stanford University scientists have implicated a logjam of three long, stringy substances behind deadly thick sputum in COVID-19 patients who need a machine to help them breathe. One of these substances may prove especially ...

Medical research

UHRF1 suppresses pathogeneses in rheumatoid arthritis

Rheumatoid arthritis (RA) is characterized by chronic inflammation of synovium, eventually leading to joint destruction. Epigenetic alteration (the mechanism of gene expression regulation without DNA sequence changes), such ...

Cardiology

New research reveals how the heart repairs after a heart attack

Immune response and the lymphatic system are central to cardiac repair after a heart attack, according to a study from Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg Cardiovascular ...

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