Journal of Clinical Investigation

Journal of Clinical Investigation is a journal published by the American Society for Clinical Investigation.

Publisher
American Society for Clinical Investigation
Country
United States
History
1924
Impact factor
14.152 (2010)

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Neuroscience

Obesity: The key role of a brain protein revealed

Regardless of how much you exercise or how balanced your diet is, controlling your weight is more brain-related than you might have thought. In a study published in the Journal of Clinical Investigation, researchers from ...

Medical research

Researchers find protein that suppresses muscle repair in mice

Researchers report that a protein known to be important to protein synthesis also influences muscle regeneration and regrowth in an unexpected manner. The discovery, reported in the Journal of Clinical Investigation, could ...

Diseases, Conditions, Syndromes

Study links patrolling monocytes to lupus-related kidney disease

A study led by St. Jude Children's Research Hospital has found evidence suggesting that patrolling monocytes may drive glomerulonephritis, inflammation of the kidneys, in patients with lupus. The findings overturn the previously ...

Medications

New drug mimics benefits of ketamine for depression

A new small-molecule drug produced a rapid antidepressant response similar to that of ketamine when tested in mice, a new Yale-led study published April 16 in the Journal of Clinical Investigation shows.

Neuroscience

Study: Protein key to charcot-marie-tooth, other nerve diseases

A new study provides critical insight into a little-known, yet relatively common, inherited neurological condition called Charcot-Marie-Tooth disease. The findings point to a pathway to possible treatments for this disease ...

Inflammatory disorders

New therapeutic strategy to prevent gastrointestinal disease

Food allergies, celiac disease, inflammatory bowel disease (IBD), diarrhea and other gastrointestinal diseases have something in common: all have been linked to epithelial barrier loss. The gut epithelial barrier—that critical ...

Cancer

Glowing tumors show scientists where cancer drugs are working

Experimenting with mice, Johns Hopkins researchers report they have successfully used positron emission tomography (PET) scans to calculate in real time how much of an immunotherapy drug reaches a tumor and what parts of ...

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