Journal of Clinical Investigation
Transplant experts challenge assumption, describe pathway that leads to organ rejection
Transplant researchers at the University of Pittsburgh School of Medicine challenge a long-held assumption about how biologic pathways trigger immune system rejection of donor organs in a report published online today in ...
Medical research
May 15, 2013 |
4.8 / 5 (4) |
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Gene replacement in pigs ameliorates cystic fibrosis-associated intestinal obstruction
Cystic fibrosis (CF) is caused by mutations in CFTR and is characterized by dysfunction of the lungs, liver, pancreas, and intestines. Approximately 15% of babies with CF are born with an obstruction of the small intestine ...
Diseases, Conditions, Syndromes
May 08, 2013 |
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Alzheimer's disease is associated with removal of the synaptic protein ADAM10
Alzheimer's disease is characterized by the accumulation of neurotoxic β-amyloid peptide (A-beta). ADAM10, a protein that resides in the neural synapses, has previously been shown to prevent the formation of A-beta.
Alzheimer's disease & dementia
May 08, 2013 |
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Differences between 'marathon mice' and 'couch potato mice' reveal key to muscle fitness
Researchers discovered that small pieces of genetic material called microRNAs link the two defining characteristics of fit muscles: the ability to burn sugar and fat and the ability to switch between slow- ...
Medical research
May 08, 2013 |
5 / 5 (2) |
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HPV leaves its mark in oropharyngeal squamous cell carcinoma
Oropharyngeal squamous cell carcinoma (OPSCC) is a form of cancer that affects the cells lining the middle part of the throat, including the soft palate, the base of the tongue, the tonsils, and the pharynx.
Cancer
May 01, 2013 |
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Searching for therapeutic synergy in primary effusion lymphoma
Primary effusion lymphoma (PEL) is a rare, fatal form of aggressive B-cell lymphoma caused by Kaposi's sarcoma-associated herpesvirus (KSHV). The disease most commonly occurs in immunocompromised patients, such as those with ...
Cancer
May 01, 2013 |
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Baby knows best: Fetuses emit hormone crucial to preventing preeclampsia
In a study using mice, researchers from the University of North Carolina at Chapel Hill found that a hormone, adrenomedullin, plays a crucial role in preventing the pregnancy complication preeclampsia. Surprisingly, ...
Medical research
May 01, 2013 |
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Rare, lethal childhood disease tracked to protein
A team of international researchers led by Northwestern Medicine scientists has identified how a defective protein plays a central role in a rare, lethal childhood disease known as Giant Axonal Neuropathy, or GAN. The finding ...
Medical research
Apr 29, 2013 |
5 / 5 (1) |
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No rebirth for insulin secreting pancreatic beta cells
Pancreatic beta cells store and release insulin, the hormone responsible for stimulating cells to convert glucose to energy. The number of beta cells in the pancreas increases in response to greater demand for insulin or ...
Medical research
Apr 24, 2013 |
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Firefly protein lights up degenerating muscles, aiding muscular-dystrophy research
Stanford University School of Medicine scientists have created a mouse model of muscular dystrophy in which degenerating muscle tissue gives off visible light. The observed luminescence occurs only in damaged muscle tissue ...
Medical research
Apr 24, 2013 |
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A potential biomarker for pregnancy-associated heart disease?
Peripartum cardiomyopathy (PPCM) is a deterioration in cardiac function that occurs in pregnant women during the last month or in the months following their pregnancy. This disorder can occur in women with no prior history ...
Diseases, Conditions, Syndromes
Apr 24, 2013 |
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Dopamine-producing neurons derived from bone marrow stem cells yield improvements in monkeys with Parkinson's disease
Parkinson's disease is a neurodegenerative disorder characterized by the death of dopamine-producing neurons in the midbrain, resulting in motor symptoms such as tremors and stiffness. The cause of cell death ...
Parkinson's & Movement disorders
Apr 22, 2013 |
5 / 5 (1) |
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Transcription factors regulating blood oxygen linked to melanoma metastases
Researchers at the University of North Carolina have discovered that transcription factors regulating the levels of oxygen in the blood also play a role in the spread of the skin cancer melanoma.
Cancer
Apr 16, 2013 |
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Resistance is futile: Researchers identify gene that mediates cisplatin resistance in ovarian cancer
Platinum compounds, such as cisplatin and carboplatin, induce DNA cross-linking, prohibiting DNA synthesis and repair in rapidly dividing cells. They are first line therapeutics in the treatment of many solid tumors, but ...
Cancer
Apr 15, 2013 |
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Researchers untangle molecular pathology of giant axonal neuropathy
Giant axonal neuropathy (GAN) is a rare genetic disorder that causes central and peripheral nervous system dysfunction. GAN is known to be caused by mutations in the gigaxonin gene and is characterized by tangling and aggregation ...
Neuroscience
Apr 15, 2013 |
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