Science Signaling
Study reveals new mechanism for estrogen suppression of liver lipid synthesis
By discovering the new mechanism by which estrogen suppresses lipid synthesis in the liver, UC Irvine endocrinologists have revealed a potential new approach toward treating certain liver diseases.
Medical research
May 23, 2013 |
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Researchers describe how breast cancer cells acquire drug resistance
A seven-year quest to understand how breast cancer cells resist treatment with the targeted therapy lapatinib has revealed a previously unknown molecular network that regulates cell death. The discovery provides new avenues ...
Cancer
May 07, 2013 |
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Researchers discover possible trigger for spread of head and neck cancer cells
(Medical Xpress)—Very little has been known about the epigenetic events—developmental and environmental factors affecting genes—that occur prior to the invasive growth of head and neck squamous cell carcinomas and their ...
Cancer
May 08, 2013 |
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Cancer gene family member functions key to cell adhesion and migration
The WTX gene is mutated in approximately 30 percent of Wilms tumors, a pediatric kidney cancer. Like many genes, WTX is part of a family. In this case, WTX has two related siblings, FAM123A and FAM123C. While ...
Cancer
Aug 30, 2012 |
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Novel discovery links anti-cancer drugs to muscle repair
Few drugs are available to treat muscle injury, muscle wasting and genetic disorders causing muscle degeneration, such as Duchenne muscular dystrophy. A compelling discovery that may change this was made recently by a research ...
Medical research
Oct 16, 2012 |
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Unexpected signaling role for foul-smelling hydrogen sulfide in cell response to protein misfolding
Something rotten never smelled so sweet. This is what members of a team of scientists at Cold Spring Harbor Laboratory (CSHL) are telling one another as they discuss a new finding they did not expect to make. They have discovered ...
Medical research
Dec 13, 2011 |
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Hope in stopping melanoma from spreading: Study shows that inhibiting key protein prevents metastasis to lungs in mice
(Medical Xpress)—Researchers have identified a critical protein role in the metastasis of melanoma, the most serious form of skin cancer. Inhibition of the protein known as adenosine diphosphate ribosylation ...
Cancer
Mar 05, 2013 |
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Study shows how vitamin E can help prevent cancer
Researchers have identified an elusive anti-cancer property of vitamin E that has long been presumed to exist, but difficult to find.
Cancer
Mar 14, 2013 |
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Master switch discovery could provide road map for treatment of arthritis and other inflammatory diseases
(Medical Xpress)—Scientists trying to create drugs to treat chronic inflammation in diseases like arthritis now have a new culprit known MMP2. New University of British Columbia research shows that this enzyme works as ...
Inflammatory disorders
Jan 23, 2013 |
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Protein in fat cells that stimulates inflammatory signaling helps put gears in motion for onset of diet-induced obesity
Poor diet and lifestyle choices set the stage for obesity and diabetes, but the immune system plays a relatively underappreciated role in accelerating this process. Metabolic changes in fat cells stimulate ...
Medical research
Mar 15, 2013 |
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How 'beige' fat makes the pounds melt away
Researchers from the University of Bonn and the Max Planck Institute of Biochemistry in Martinsried have decoded a signal path that could boost the burning of body fat. Mice that are missing a signal switch called VASP are ...
Medical research
Aug 28, 2012 |
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Proteins in DNA damage response network targeted for new therapies, researchers say
(Medical Xpress)—Researchers at Moffitt Cancer Center and colleagues at the University of South Florida; Duke University; Johns Hopkins University; the Brazilian National Cancer Institute; and the Rio de Janeiro Federal ...
Medical research
Oct 16, 2012 |
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A new starring role for astrocytes
Astrocytes, previously thought of as helper cells for neurons, have recently been shown to send signals themselves. The signals are chemical not electrical and astrocytes send them to neurons, vascular ...
Medical research
Aug 10, 2012 |
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How a quirky fruit fly gene could help researchers develop new cancer drugs
(Medical Xpress) -- Loyola researchers are taking advantage of a quirk in the evolution of fruit fly genes to help develop new weapons against cancer.
Genetics
Jun 14, 2012 |
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'Master molecule' may improve stem cell treatment of heart attacks
Johns Hopkins researchers have discovered that a single protein molecule may hold the key to turning cardiac stem cells into blood vessels or muscle tissue, a finding that may lead to better ways to treat heart attack patients.
Cardiology
Jun 20, 2012 |
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