Virtual lung models set to personalize asthma and COPD treatment

May 3, 2011

A team of international experts are set to develop a pioneering tool to help tailor the treatment of asthma and chronic obstructive pulmonary disease (COPD) as part of a new EU project.

The 5-year AirPROM project, which is being launched this month (May 2011), will create computed and physical models of the whole airways system, to help scientists and doctors predict how patients might react to different treatments.

The news comes on World Day (3 May 2011), which aims to raise awareness about asthma and improve asthma care throughout the world.

Damaged, inflamed or obstructed airways are common in people with COPD and asthma, which makes breathing difficult. The current methods to detect and treat these conditions do not always consider individual differences in the airways that make each person unique. As a consequence, people with these conditions may not receive the most effective treatment.

Whilst scientists are working on more advanced, targeted approaches to treatment, they have often been unable to match these treatments to the right patients and explain the reasons behind this until now.

The AirPROM research team, which involves scientists from over 10 European countries, will make a computed model of the in an airway and a physical model of the airways, to assess how air flows through the lungs and why it becomes obstructed in people with asthma and COPD.

By using these unique models, along with existing data from tests which measure and highly detailed x-rays, known as CT scans, the scientists will be able test new therapies, which will enable them to tailor treatments to the individual.

The aim is to use this information to generate an extensive database that will be able to link the characteristics of different airways to a particular treatment in the future, helping health professionals provide personalised treatment for people with COPD and asthma.

These tools will also help scientists predict how the diseases will progress and the effect on the airways, to help monitor the future risk to patients.

Professor Chris Brightling, project lead, said: "Current treatments for COPD and asthma adopt a 'one size fits all' approach. People with these respiratory diseases are therefore missing out on the right treatment to help them manage their condition. These patient-specific models will help us monitor the diseases and how they progress, to make current treatments much more specific and targeted to benefit COPD and asthma patients.

Our ability to create a model of the lung using CT scans and other data has advanced greatly along with our ability to measure genes and their activity. We are also at a point in time where computational models have advanced to the point where they can be used to make sense of 1000s of measurements. Now is the time to bring all these elements together to change the way diagnose patients"

Breda Flood, a patient with asthma and board member of European Federation of Allergy and Airways Diseases Patients Association (EFA), said: "This new model will help us to visualise activity in our lungs and see how our illness affects our breathing. By gaining an insight into how specific treatments will work, patients will have a better understanding of how to manage their condition in the future."

Related Stories

Recommended for you

Antibody found that fight MERS coronavirus

July 28, 2015

(Medical Xpress)—An international team of researchers has found a MERS neutralizing antibody—a discovery that could perhaps lead to a treatment for people infected with the virus. In their paper published in Proceedings ...

Experimental MERS vaccine shows promise in animal studies

July 28, 2015

A two-step regimen of experimental vaccines against Middle East respiratory syndrome (MERS) prompted immune responses in mice and rhesus macaques, report National Institutes of Health scientists who designed the vaccines. ...

Can social isolation fuel epidemics?

July 21, 2015

Conventional wisdom has it that the more people stay within their own social groups and avoid others, the less likely it is small disease outbreaks turn into full-blown epidemics. But the conventional wisdom is wrong, according ...

Lack of knowledge on animal disease leaves humans at risk

July 20, 2015

Researchers from the University of Sydney have painted the most detailed picture to date of major infectious diseases shared between wildlife and livestock, and found a huge gap in knowledge about diseases which could spread ...

IBD genetically similar in Europeans and non-Europeans

July 20, 2015

The first genetic study of inflammatory bowel disease (IBD) to include individuals from diverse populations has shown that the regions of the genome underlying the disease are consistent around the world. This study, conducted ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.