Genetically engineered cardiac stem cells repaired damaged mouse heart

July 19, 2011

Genetically engineered human cardiac stem cells helped repair damaged heart tissue and improved function after a heart attack, in a new animal study.

Stem cells can potentially develop into multiple types of tissue and can also regenerate, unlike other kinds of cells.

Ten weeks after investigators implanted the genetically engineered human into mice, and function, as measured by the heart’s ability to pump blood, was twice that of controls. This improvement persisted for at least 20 weeks after implantation.

“This study brings us one step closer to a clinical application for stem-cell therapy,” said Sadia Mohsin, Ph.D., lead author of the study and post-doctoral research scholar at San Diego State University in California. “Since patients with heart failure are normally elderly, their cardiac stem cells aren’t very healthy. We were able to modify these stem cells, obtained from heart failure patients, to be healthier so that they could be transplanted into the heart and survive and thrive.”

Researchers used cardiac stem cells from patients receiving mechanical assist device pumps to help their failing hearts. They then genetically engineered the cells to express a protein, known as Pim-1, which naturally occurs in response to heart damage. Using molecular technology, they attached this protein to another, derived from jellyfish, which glows fluorescent green so that Pim-1 expression was clearly visible.

After implanting the genetically engineered Pim-1 and non-modified human cardiac cells into a mouse challenged with an experimentally-induced , the researchers compared heart function between the two groups.

Researchers said this application “has emerged as a viable option addressing current limitations associated with stem cell therapy.”

Explore further: Helping the heart help itself: Research points to new use for stem cells

Related Stories

Recommended for you

Regular exercise critical for heart health, longevity

January 18, 2016

The majority of citizens in developed countries should not be concerned by potential harm from exercise but rather by the lack of exercise in their lives, according to a clinical perspective published today in the Journal ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.