Evidence for spinal membrane as a source of stem cells may advance spinal cord treatment
Italian and Spanish scientists studying the use of stem cells for treating spinal cord injuries have provided the first evidence to show that meninges, the membrane which envelops the central nervous system, is a potential source of self-renewing stem cells. The research, published in Stem Cells, develops the understanding of cell activation in central nervous system injuries; advancing research into new treatments for spinal injuries and degenerative brain disorders.
The team focused their research on spinal cord injuries, caused when the spinal cord is damaged by trauma rather than disease. Depending on the severity a spinal injury can lead from pain to full paralysis, with high social and medical care costs. As the spinal cord lacks the ability to regenerate, the potential for patient recovery is severely limited.
"Our research offers the first evidence that the spinal cord meninges, the system of membranes which cover the surface of the brain and the spinal cord, contains stem cells which are capable of self-renewal and proliferation," said lead authors Dr Ilaria Decimo and Dr Francesco Bifari, at the University of Verona.
Following a spinal injury meningeal cells increase in number and migrate to form glial scars and the team believe this process explains part of the mechanism of stem cell activation in central nervous system diseases; a mechanism which could in turn be used for treatments. Dr Decimo's team microdissected samples of spinal cord meninges from adult rats revealing that meningeal cells contain crucial stem cell properties. It is these properties which increase following a spinal cord injury.
"Our research emphasizes the role of meninges cells in the reaction to spinal cord trauma and indicates for the first time that spinal cord meninges harbour stem cells which are activated by injury," concluded Dr, Decimo. "Further testing could result in a strategic turnaround for advancing regenerative medicine for treating neurological disorders and spinal cord injuries."
"This study underlines the importance of endogenous stem cells," said Stem Cells Editor Dr Miodrag Stojkovic. "Identification of these cells is crucial for understanding the basic mechanisms of cell biology and tissue repair, but also to identify drugs and chemicals which might be used to mobilize meningeal stem cells."
Provided by Wiley
- Stem cells used to reverse paralysis in animals Jan 28, 2009 | not rated yet | 0
- Damaged spinal cord tissue repaired by stem cells Oct 08, 2010 | not rated yet | 0
- Human stem cell transplants mature into neurons and make contacts in rat spinal cord Feb 13, 2007 | not rated yet | 0
- Study: Spinal cord can repair itself Feb 14, 2007 | not rated yet | 0
- New spinal cord injury therapy developed Jul 25, 2007 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Why is zone 1 in liver more prone to ischemic injury?
13 hours ago Hi, Is it because around central vein, there is only deoxygenated blood from the vein where as in the periphery there is hepatic artery. Also why...
How can there be villous adenoma in colon, if there are no villi there
May 22, 2013 As title suggest. Thanks :smile:
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013 Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
- More from Physics Forums - Medical Sciences
More news stories
By discovering the new mechanism by which estrogen suppresses lipid synthesis in the liver, UC Irvine endocrinologists have revealed a potential new approach toward treating certain liver diseases.
Medical research 1 hour ago | not rated yet | 0 |
Aortic arch pulse wave velocity, a measure of arterial stiffness, is a strong independent predictor of disease of the vessels that supply blood to the brain, according to a new study published in the June issue the journal ...
Medical research 1 hour ago | not rated yet | 0
Since the discovery of Prontosil in 1932, sulfonamide antibiotics have been used to combat a wide spectrum of bacterial infections, from acne to chlamydia and pneumonia. However, their side effects can include serious neurological ...
Medical research 2 hours ago | not rated yet | 0 |
Scientists at the National Institutes of Health report they have discovered in mouse studies that a small molecule released in the spinal cord triggers a process that is later experienced in the brain as the sensation of ...
Medical research 3 hours ago | 5 / 5 (1) | 0 |
Spanish researchers have discovered that the daily clearance of neutrophils from the body stimulates the release of hematopoietic stem cells from the bone marrow into the bloodstream, according to a report published today ...
Medical research 4 hours ago | 5 / 5 (1) | 0
Even while being dragged to its destruction inside a cell, a cancer-promoting growth factor receptor fires away, sending signals that thwart the development of tumor-suppressing microRNAs (miRNAs) before it's dissolved, researchers ...
29 minutes ago | not rated yet | 0 |
Ethnic background plays a surprisingly large role in how diabetes develops on a cellular level, according to two new studies led by researchers at the Stanford University School of Medicine.
57 minutes ago | not rated yet | 0 |
Finnish researchers unveiled new data Thursday to link the Pandemrix flu vaccine to a higher risk of the sleeping disorder narcolepsy in adults.
29 minutes ago | not rated yet | 0
Maintaining a heart healthy lifestyle may also help protect chronic kidney disease patients from developing kidney failure and dying prematurely, according to a study appearing in an upcoming issue of the Journal of the Am ...
4 seconds ago | not rated yet | 0
(AP)—Johnson & Johnson is developing what could eventually be game-changing treatments for depression and pain, and it's aiming to apply for approval of more than 10 new medicines by 2017, executives said Thursday during ...
20 minutes ago | not rated yet | 0