Study indicates that induced labor may not lower risk of infection or respiratory problems in newborns

In a study to be presented today at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting, in Dallas, Texas, researchers will report findings that suggest that induction of labor in patients who suffer a rupture of membranes between the 34th and 37th week of gestation (before the onset of labor) does not reduce the risk of infection or respiratory problems in the newborn.

"Our research indicates that in patients who underwent close monitoring, known as expectant management, versus those whose labor was induced, there was no difference in the risk for infection in the newborn, breathing problems in the newborn or caesarean section rates," said David van der Ham, MD, with the Maastricht University Medical Center, & Gynecology, GROW School for Oncology and Developmental Biology, Maastricht, Netherlands, and one of the study's authors. "Due to these findings, we suggested expectant management as opposed to induced labor when possible."

For the study, entitled Induction of Labor Versus Expectant Management in Women with Preterm Prelabor Rupture of Membranes Between 34 and 37 Weeks– the PPROMEXIL-2 trial, van der Ham and his colleagues observed 536 women from January 2007 until September 2009, and 195 women from December 2009 until January 2011. The study was performed in a multicenter setting within the Dutch obstetric research consortium, in which 60 hospitals in the Netherlands collaborated. After 24 hours of ruptured membranes, patients were allocated to either immediate delivery or expectant management until 37 weeks of gestational age.

The results indicate that: expectant management prolonged for 3.5 days; the risk for neonatal sepsis (infection of the newborn) overall was low (3.6%) and did not differ between ; the risk for respiratory distress syndrome (breathing problems of the newborn) did not differ between treatment strategies; and rates were equal in both treatment strategies. Combined with results of all previous published trials there was no difference in the identified risks.

In addition to van der Ham, the study was conducted by Jantien van der Heijden and Hans van Beek, VieCuri Medical Center, Obstetrics & Gynecology, Venlo, Netherlands; Brent Opmeer, Academic Medical Center, Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam, Netherlands; Christine Willekes and Jan Nijhuis, Maastricht University Medical Center, Obstetrics & Gynecology, GROW School for Oncology and Developmental Biology, Maastricht, Netherlands; Twan Mulder, Maastricht University Medical Center, Pediatrics, Maastricht, Netherlands; Rob Moonen, Atrium Medical Center, Pediatrics, Heerlen, Netherlands; Marielle van Pampus, University Medical Center Groningen, Obstetrics and Gynecology, Groningen, Netherlands; Mariet Groenewout, University Medical Center Groningen, Obstetrics & Gynecology, Groningen, Netherlands; Gerald Mantel, Isala klinieken, Obstetrics & Gynecology, Zwolle, Netherlands; Anneke Kwee, Dutch consortium AMPHIA trial, Netherlands; Hajo Wildschut, Erasmus Medical Center, Obstetrics & Gynecology, Rotterdam, Netherlands; Bettina Akerboom, Albert Schweitzer Hospital, Obstetrics and , Dordrecht, Netherlands; and Ben Mol, Academic Medical Center, Department of Obstetrics and Gynaecology, Amsterdam, Netherlands.

More information: A copy of the abstract is available at www.smfmnewsroom.org/annual-me… 1-meeting-abstracts/

Related Stories

Study finds residence in US a risk factor for preterm birth

date Feb 09, 2012

In a study to be presented today at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting, in Dallas, Texas, researchers will report findings that indicate that duration of stay in the United States ...

Recommended for you

Running with prosthetic lower-limbs

date Jun 29, 2015

Researchers at Bournemouth University have been looking at the impact of lower-limb prosthetics on competitive running, specifically looking at whether athletes with prosthesis are at an unfair advantage when running against ...

Nature's lubricant makes your body a well-oiled machine

date Jun 25, 2015

The old adage goes that the human body is a machine. And in many ways that isn't far from the truth. Like any machine, the human body is made up of many individual parts moving together in a highly coordinated ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.