Risk of sudden cardiac death up for black patients with HTN

Risk of sudden cardiac death up for black patients with HTN
Black patients with hypertension face a significantly increased risk of sudden cardiac death compared with nonblack patients, even after adjusting for multiple confounding variables, according to a study published in the April issue of Heart Rhythm.

(HealthDay) -- Black patients with hypertension face a significantly increased risk of sudden cardiac death (SCD) compared with nonblack patients, even after adjusting for multiple confounding variables, according to a study published in the April issue of Heart Rhythm.

Peter M. Okin, M.D., from Cornell University in New York City, and colleagues examined the incidence of SCD in 533 black and 8,660 nonblack hypertensive patients with electrocardiographic left ventricular hypertrophy. Patients were randomly assigned to losartan- or atenolol-based treatment and were followed for a mean of 4.8 years.

The researchers found that SCD occurred in 1.9 percent of patients. Compared with nonblack patients, the five-year SCD incidence was significantly higher in black patients (3.9 versus 1.9 percent; P = 0.007). In univariate analyses, black patients had a significantly increased risk of SCD (hazard ratio, 1.97; P= 0.015). After adjustment for other sociodemographic and medical variables, black race remained similarly associated with an increased risk of SCD (hazard ratio, 1.98; P = 0.02).

"The higher risk of SCD in black patients persists after adjusting for the higher prevalence of risk factors in black patients, in-treatment blood pressure, and the established predictive value of in-treatment electrocardiographic left ventricular hypertrophy and heart rate for SCD in this population," the authors write.

Several authors disclosed to pharmaceutical companies, including Merck & Co., which partially supported this research.

More information: Abstract
Full Text

add to favorites email to friend print save as pdf

Related Stories

Anticancer drugs might be of benefit to sickle-cell patients

Dec 06, 2007

Sickle cell disease (SCD) is an inherited blood disorder caused by a genetic mutation that leads to the generation of a mutant form of the beta-globin chain of hemoglobin (Hb). Red blood cells containing Hb with this mutant ...

Black patients at higher risk for colon polyps

Sep 23, 2008

Compared with white patients, black patients undergoing screening colonoscopy have a higher prevalence of colon polyps, according to a study in the September 24 issue of JAMA.

Recommended for you

Real-time volume imaging of hearts

7 hours ago

A new ultrasound system from Siemens enables doctors to carry out heart examinations through the esophagus for the first time. The system supplies 3D images of the heart as well as additional real-time information ...

Post-PCI bleeding rates vary widely across hospitals

Nov 27, 2014

(HealthDay)—Patient case-mix and procedural factors may contribute to wide variation in the hospital rates of bleeding after percutaneous coronary intervention (PCI), according to research published online ...

Most seniors eligible for statin Rx under new guidelines

Nov 25, 2014

(HealthDay)—Most older Americans qualify for treatment with statins under new guidelines for the treatment of blood cholesterol released late last year by the American College of Cardiology and the American ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.