Risk of sudden cardiac death up for black patients with HTN

Risk of sudden cardiac death up for black patients with HTN
Black patients with hypertension face a significantly increased risk of sudden cardiac death compared with nonblack patients, even after adjusting for multiple confounding variables, according to a study published in the April issue of Heart Rhythm.

(HealthDay) -- Black patients with hypertension face a significantly increased risk of sudden cardiac death (SCD) compared with nonblack patients, even after adjusting for multiple confounding variables, according to a study published in the April issue of Heart Rhythm.

Peter M. Okin, M.D., from Cornell University in New York City, and colleagues examined the incidence of SCD in 533 black and 8,660 nonblack hypertensive patients with electrocardiographic left ventricular hypertrophy. Patients were randomly assigned to losartan- or atenolol-based treatment and were followed for a mean of 4.8 years.

The researchers found that SCD occurred in 1.9 percent of patients. Compared with nonblack patients, the five-year SCD incidence was significantly higher in black patients (3.9 versus 1.9 percent; P = 0.007). In univariate analyses, black patients had a significantly increased risk of SCD (hazard ratio, 1.97; P= 0.015). After adjustment for other sociodemographic and medical variables, black race remained similarly associated with an increased risk of SCD (hazard ratio, 1.98; P = 0.02).

"The higher risk of SCD in black patients persists after adjusting for the higher prevalence of risk factors in black patients, in-treatment blood pressure, and the established predictive value of in-treatment electrocardiographic left ventricular hypertrophy and heart rate for SCD in this population," the authors write.

Several authors disclosed to pharmaceutical companies, including Merck & Co., which partially supported this research.

More information: Abstract
Full Text

add to favorites email to friend print save as pdf

Related Stories

Anticancer drugs might be of benefit to sickle-cell patients

Dec 06, 2007

Sickle cell disease (SCD) is an inherited blood disorder caused by a genetic mutation that leads to the generation of a mutant form of the beta-globin chain of hemoglobin (Hb). Red blood cells containing Hb with this mutant ...

Black patients at higher risk for colon polyps

Sep 23, 2008

Compared with white patients, black patients undergoing screening colonoscopy have a higher prevalence of colon polyps, according to a study in the September 24 issue of JAMA.

Recommended for you

Gene variant raises risk for aortic tear and rupture

19 hours ago

Researchers from Yale School of Medicine and Celera Diagnostics have confirmed the significance of a genetic variant that substantially increases the risk of a frequently fatal thoracic aortic dissection or full rupture. ...

Considerable variation in CT use in ischemic stroke

19 hours ago

(HealthDay)—For patients with ischemic stroke there is considerable variation in the rates of high-intensity computed tomography (CT) use, according to a study published online April 8 in Circulation: Ca ...

Beating the clock for ischemic stroke sufferers

Apr 17, 2014

A ground-breaking computer technology raises hope for people struck by ischemic stroke, which is a very common kind of stroke accounting for over 80 per cent of overall stroke cases. Developed by research experts at The Hong ...

Risk for nonelective thoracic aortic sx up for uninsured

Apr 16, 2014

(HealthDay)—Uninsured patients have an increased risk of nonelective thoracic aortic operations, and have increased risks of major morbidity or mortality, according to a study published online April 8 in ...

User comments