Obesity, overweight at diagnosis ups B-cell lymphoma prognosis

May 30, 2012
Obesity, overweight at diagnosis ups B-Cell lymphoma prognosis
For U.S. veterans with diffuse large B-cell lymphoma, being overweight or obese at time of diagnosis correlates with improved survival, according to a study published online May 29 in the Journal of Clinical Oncology.

(HealthDay) -- For U.S. veterans with diffuse large B-cell lymphoma (DLBCL), being overweight or obese at time of diagnosis correlates with improved survival, according to a study published online May 29 in the Journal of Clinical Oncology.

To investigate the association between (BMI) at diagnosis and overall survival, Kenneth R. Carson, M.D., from the St. Louis Veterans Affairs Medical Center, and colleagues conducted a involving 2,534 U.S. veterans diagnosed with DLBCL from 1998 to 2008.

The researchers found that the mean age at diagnosis was 68 years, and 64 percent of patients were overweight or obese. Compared with other BMI groups, obese patients were significantly younger, had significantly fewer B symptoms, and showed a trend toward lower-stage disease. Compared with normal-weight patients, Cox analysis showed decreased mortality for overweight and obese patients (hazard ratios, 0.73 and 0.68, respectively). Treatment during the rituximab era attenuated the but did not impact the association between BMI and survival. One year before diagnosis, disease-related weight loss occurred in 29 percent of patients with weight data, but Cox analysis based on BMI one year before diagnosis showed a persistent association between overweight/obesity and reduced mortality risk.

"Being overweight or obese at the time of DLBCL diagnosis is associated with improved overall survival," the authors write. "Understanding the mechanisms responsible for this association will require further study."

One author disclosed a financial relationship with Genentech.

Explore further: Physician's weight may influence obesity diagnosis and care

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Physician's weight may influence obesity diagnosis and care

January 26, 2012

A patient's body mass index (BMI) may not be the only factor at play when a physician diagnoses a patient as obese. According to a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health, the diagnosis ...

Lower all-Cause, cardio mortality in obese with RA

May 2, 2012

(HealthDay) -- Overweight and obese patients with rheumatoid arthritis (RA) have lower all-cause and cardiovascular mortality, but have substantially increased risks of comorbidities, medical costs, and reduced quality of ...

Recommended for you

Genetic sequencing reveals drug resistance growth

May 25, 2016

The rate at which genetically mutated cancer cells grow may help explain why patients with a common form of leukemia develop treatment resistance, according to new research led by a Weill Cornell Medicine investigator. The ...

Taking control of key protein stifles cancer spread in mice

May 20, 2016

For cancer to spread, the cells that take off into the bloodstream must find a tissue that will permit them to thrive. They don't just go looking, though. Instead, they actively prepare the tissue, in one case by co-opting ...

Cancer can be combated with reprogrammed macrophage cells

May 20, 2016

Researchers at Karolinska Institutet have generated antibodies that reprogramme a type of macrophage cell in the tumour, making the immune system better able to recognise and kill tumour cells. The study, which is published ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.