Peptide level ups diagnosis of heart failure in primary care

To evaluate the additional use of BNP levels to diagnose heart failure in the primary care setting, Emanuel Burri, M.D., of the University Hospital Basel in Switzerland, and colleagues conducted a randomized, controlled trial involving 323 patients with dyspnea treated by 29 primary care physicians in Germany and Switzerland. Participants were assigned in a 1:1 ratio to receive point-of-care measurement of BNP or standard assessment without BNP.

The researchers found that 34 percent of patients presenting with dyspnea to their primary care physicians were ultimately diagnosed with heart failure. Compared with standard assessment, addition of BNP measurement did not decrease the number of hospitalizations, functional status, or total medical costs at three months. However, the additional use of BNP significantly increased diagnostic certainty, indicated by a reduced need for further diagnostic work-up (33 versus 45 percent; P = 0.02), and sped up the initiation of appropriate treatment (13 versus 25 days; P = 0.01).

"The measurement of BNP levels in primary care did not reduce total medical cost, but improved some of the secondary endpoints including an increase in diagnostic certainty and more rapid initiation of appropriate treatment," the authors write.

One of the authors disclosed financial ties to the pharmaceutical industry.

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Journal reference: Journal of Internal Medicine

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