Increased sudden cardiac death rate among HIV patients

Increased sudden cardiac death rate among HIV patients
Patients with HIV/AIDS have a significantly increased risk of sudden cardiac death, according to a study published in the May 22 issue of the Journal of the American College of Cardiology.

(HealthDay) -- Patients with HIV/AIDS have a significantly increased risk of sudden cardiac death (SCD), according to a study published in the May 22 issue of the Journal of the American College of Cardiology.

Zian H. Tseng, M.D., of the University of California in San Francisco, and associates conducted a retrospective study of 2,860 treated at a public HIV clinic in San Francisco from April 2000 to August 2009. Data were collected on deaths, cause of death, and clinical characteristics, and the link between HIV/AIDS and SCD was investigated.

During a median follow-up of 3.7 years, the researchers identified 230 deaths. Of these, 57 percent were due to AIDS; 14 percent met the criteria for SCD; 11 percent were due to natural causes; and 19 percent were due to overdoses, suicides, and unknown causes. Eighty-six percent of the (30 of 35) were due to SCD. The mean SCD rate was 4.5-fold higher than expected, at 2.6 per 1,000 person-years. Compared with AIDS deaths, SCD occurred in older patients (49.0 versus 44.9 years; P = 0.02). SCDs had a significantly higher prevalence of prior , cardiomyopathy, heart failure, and arrhythmia than AIDS and natural deaths combined.

"SCDs account for most cardiac and many non-AIDS natural deaths in HIV-infected patients," the authors write. "Further investigation is needed to ascertain underlying mechanisms, which may include inflammation, antiretroviral therapy interruption, and concomitant medications."

One author disclosed a financial relationship with Biotronik.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

More AIDS patients die of other causes

Sep 19, 2006

New York's Bureau of HIV/AIDS Prevention and Control report has said it is becoming less common for AIDS patients to die of causes related to the disease.

Recommended for you

Study: Removing clot helps limit stroke disability

Dec 17, 2014

For the first time in several decades, a new treatment has been shown to limit the damage from a common type of stroke. Researchers in the Netherlands found that mechanically removing a clot in addition to using a clot-busting ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.