Tocilizumab is more effective than adalimumab at reducing signs and symptoms of rheumatoid arthritis
Data presented today at EULAR 2012, the Annual Congress of the European League Against Rheumatism, demonstrates that tocilizumab monotherapy is more effective than adalimumab monotherapy in the treatment of rheumatoid arthritis (RA) based on change from baseline in DAS28 (-3.3 vs. -1.8, p<0.0001) at week 24. The ADACTA trial, conducted in 325 patients with RA showed that tocilizumab was more effective than adalimumab for DAS28 remission (39.9% vs 10.5%, p<0.0001), low disease activity (51.5% vs. 19.8%, p<0.0001) and ACR20/50/70 responses (65.0%, 47.2%, 32.5% respectively vs. 49.4%, 27.8%, 17.9%, p<0.01). Differences between arms were also noted in favour of tocilizumab from week eight onwards in swollen and tender joint counts, erythrocyte sedimentation rate (ESR, a test that indirectly measures the among of inflammation in the body), and patient global assessment.
"Approximately one third of patients with rheumatoid arthritis receive biologic monotherapy and this is the first head-to-head trial comparing an IL-6 inhibitor to an anti-TNF, two therapies with different modes of action," said Professor Cem Gabay from University Hospitals of Geneva, Switzerland. "This study clearly shows the benefits of tocilizumab over adalimumab on various measures of rheumatoid arthritis disease activity and is the first study of its kind to determine superiority between two approved RA drugs."
The international, multicenter, randomised, double-blind, 24 week study was designed to test for treatment superiority in patients with an RA diagnosis of greater than six months who were methotrexate intolerant or for whom continued treatment with methotrexate was inappropriate. Patients were randomly assigned to two arms for a total of 24 weeks: tocilizumab 8mg/kg IV every four weeks plus placebo or adalimumab 40mg subcutaneously every two weeks plus placebo. The primary endpoint of the study was mean change from baseline in DAS28 at 24 weeks.
The incidence of adverse events (AEs) was similar between groups, with 82.1% of patients having an AE in the tocilizumab arm and 82.7% in the adalimumab arm. Serious AEs and serious infections were also similar between groups (tocilizumab: 11.7%, 3.1%, adalimumab: 9.9%, 3.1%). Changes in transaminase, low-density lipoprotein (LDL) elevations, and neutrophil reductions occurred in both arms, with the proportion of patients with abnormal values higher in the tocilizumab arm. There were two deaths reported in the tocilizumab arm; one from sudden death and one from illicit drug overdose.
More information: Abstract Number: LB0003
Provided by European League Against Rheumatism
- Current smokers with early rheumatoid arthritis less responsive to TNF inhibitors, methotrexate Jan 04, 2011 | not rated yet | 0
- Gender, high DAS28-P index predictive of pain in early RA May 18, 2012 | not rated yet | 0
- Study confirms link between rheumatoid arthritis and COPD May 26, 2011 | not rated yet | 0
- Country economy is a stronger predictor of therapy initiation Jun 18, 2010 | not rated yet | 0
- Patients with RA receive less protection from pandemic influenza with H1N1 vaccine May 26, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Equating differentials => equating coefficients
55 minutes ago Hi all, In thermodynamics one often has equations like A dx + B dy = ∂f/∂x dx + ∂f/∂y dy From which follows A = ∂f/∂x B = ∂f/∂y
The idea behind a reverse shock
6 hours ago So in a supernova explosion for example (5th slide) http://www.astro.princeton.edu/~burrows/classes/541/blastwavesChisari.pdf Ambient medium is...
Guass's Law for a charge distribution
6 hours ago First, this is not a homework question, just something I've been confused about for some time. I understand how to use Guass's law in many ways but...
7 hours ago Hello :) i'm new to this forum, so excuse me for my straightforwardness ;) I'm working on my bachelor work and i can't find a solution. I'm writing...
siphon and bernouli theorum
9 hours ago 1. I found this diagram on book but there weren't any description.can someone tell me, what its trying to tell specially by those two red lines...
Hot gas expansion rate into outer space
9 hours ago Good Morning Sirs, it seems to be surprisingly hard to get the numbers of a mystery: How fast expand hot rocket exhaust gases into empty space? ...
- More from Physics Forums - Classical Physics
More news stories
(Medical Xpress)—UCD researchers led by Conway Fellow, Professor David Brayden in UCD School of Veterinary Medicine have successfully reduced inflammation in the swollen arthritic knees of a murine model using a novel nanoparticle.
Arthritis & Rheumatism May 24, 2013 | 5 / 5 (1) | 0
In a series of lab experiments designed to unravel the workings of a key enzyme widely considered a possible trigger of rheumatoid arthritis, researchers at Johns Hopkins have found that in the most severe ...
Arthritis & Rheumatism May 22, 2013 | 5 / 5 (3) | 0 |
(HealthDay)—Injections of a sugar solution appear to help relieve knee pain and stiffness related to osteoarthritis, a new study suggests.
Arthritis & Rheumatism May 21, 2013 | 4.5 / 5 (2) | 0 |
A novel study reports that white men and women of European descent inherit common foot disorders, such as bunions (hallux valgus) and lesser toe deformities, including hammer or claw toe. Findings from the Framingham Foot ...
Arthritis & Rheumatism May 20, 2013 | not rated yet | 0 |
Scientists at Johns Hopkins have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, ...
Arthritis & Rheumatism May 19, 2013 | 4.9 / 5 (8) | 0 |
Coenzyme Q10 decreases all cause mortality by half, according to the results of a multicentre randomised double blind trial presented today at Heart Failure 2013 congress. It is the first drug to improve heart failure mortality ...
12 hours ago | 5 / 5 (2) | 5
(HealthDay)—Animals make great companions for senior citizens, but elderly people who always drive with a pet in the car are far more likely to crash than those who never drive with a pet, researchers have ...
4 hours ago | not rated yet | 0
Heart failure accelerates the aging process and brings on early andropausal syndrome (AS), according to research presented today at the Heart Failure Congress 2013. AS, also referred to as male 'menopause', was four times ...
12 hours ago | not rated yet | 1
Mortality and length of stay are highest in heart failure patients admitted in January, on Friday, and overnight, according to research presented today at the Heart Failure Congress 2013. The analysis of nearly 1 million ...
12 hours ago | not rated yet | 0
(AP)—Department of Justice lawyers have again asked a federal appeals court in New York to delay lifting age restrictions and prescription requirements on an emergency contraceptive popularly known as the morning-after ...
11 hours ago | not rated yet | 0