Donepezil found helpful in dementia with lewy bodies

July 31, 2012
Donepezil found helpful in dementia with lewy bodies
For patients with dementia with Lewy bodies, treatment with 5 or 10 mg/day donepezil is associated with significant cognitive, behavioral, and global function improvements, according to research published in the July issue of the Annals of Neurology.

(HealthDay) -- For patients with dementia with Lewy bodies (DLB), treatment with 5 or 10 mg/day donepezil is associated with significant cognitive, behavioral, and global function improvements, according to research published in the July issue of the Annals of Neurology.

Etsuro Mori, M.D., Ph.D., of the Tohoku University Graduate School of Medicine in Sendai, Japan, and colleagues conducted a randomized, double-blind, placebo-controlled trial involving 140 patients with DLB who received either placebo or 3, 5, or 10 mg of donepezil hydrochloride per day for 12 weeks (35, 35, 33, and 37 patients, respectively). Cognitive function was measured using the Mini-Mental State Examination (MMSE); were measured using the Neuropsychiatric Inventory; global function was evaluated using the Clinician's Interview-Based Impression of Change-plus Caregiver Input (CIBIC-plus); and caregiver burden was also assessed.

The researchers found that, compared with , the MMSE scores were significantly better with donepezil 5 mg (mean difference, 3.8) and 10 mg (mean difference, 2.4), but the 3 mg/day dose was not significantly better than placebo (P = 0.017). Donepezil at doses of 3, 5, and 10 mg/day correlated with significant improvements versus on CIBIC-plus. Both the 5 and 10 mg doses of donepezil resulted in significant improvements in . Caregiver burden also improved, but only with the 10 mg/day dose. The safety results were similar among the groups and were consistent with the known profile.

"Donepezil at 5 and 10 mg/day produces significant cognitive, behavioral, and global improvements that last at least 12 weeks in DLB patients, reducing caregiver burden at the highest dose," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Eisai Co., which funded the study and manufactures donepezil.

Explore further: Sumatriptan/Naproxen helpful in treating teens' migraines

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Prophylaxis with apixaban feasible for cancer patients

March 29, 2012

(HealthDay) -- Primary venous thromboembolism prophylaxis with apixaban, an oral direct Factor Xa inhibitor, in ambulatory cancer patients undergoing first- or second-line chemotherapy for advanced or metastatic cancer, is ...

ECO: New weight loss drug effective in advanced obesity

May 14, 2012

(HealthDay) -- A new combination treatment of controlled-release phentermine/topiramate (PHEN/TPM CR) leads to significantly greater weight loss than a placebo even in individuals with significant obesity-related comorbidities, ...

Belimumab deemed safe for long-term lupus treatment

June 19, 2012

(HealthDay) -- For patients with systemic lupus erythematosus (SLE), long-term belimumab therapy combined with standard therapy is well tolerated, according to a study published online June 5 in Arthritis & Rheumatism.

Recommended for you

Autism-linked protein crucial for feeling pain

December 1, 2016

Sensory problems are common to autism spectrum disorders. Some individuals with autism may injure themselves repetitively—for example, pulling their hair or banging their heads—because they're less sensitive to pain than ...

Study provides neuronal mechanism for the benefits of fasting

December 1, 2016

A study from the Buck Institute offers for the first time an explanation for the benefits of fasting at the neuronal level, providing a possible mechanism for how fasting can afford health benefits. Publishing on December ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.