Free light chains identified in chronic rhinosinusitis

July 16, 2012 in Immunology

Free light chains identified in chronic rhinosinusitis

Patients with chronic rhinosinusitis (CRS) have increased free light chain concentrations, particularly those with CRS with nasal polyps, according to a study published online July 5 in Allergy.

(HealthDay) -- Patients with chronic rhinosinusitis (CRS) have increased free light chain (FLC) concentrations, particularly those with CRS with nasal polyps (CRSwNP), according to a study published online July 5 in Allergy.

Tom Groot Kormelink, of Utrecht University in the Netherlands, and associates analyzed nasal tissue, nasal , and serum of patients with CRSwNP and CRS without nasal polyps (CRSsNP) to determine the presence of FLCs. The effect of different treatments on the expression of FLCs was examined.

The researchers found that patients with CRS had increased FLC concentrations in nasal secretion and mucosal tissue homogenates, and the increase was most prominent in patients with CRSwNP. The increase in FLC in nasal polyp tissue was confirmed by immunohistochemistry. Treatment with methylprednisolone or anti--5 (IL-5) resulted in the reduction in systemic or local FLC concentrations, respectively, in patients with CRSwNP.

"The presence of FLC in CRSwNP and CRSsNP suggests a possible role in mediating the local in the paranasal ," the authors write. "Furthermore, the decrease in local FLCs after treatment with anti-IL-5 presumes that IL-5 creates an environment that favors FLC production."

More information: Abstract
Full Text (subscription or payment may be required)

Journal reference: Allergy search and more info website

Copyright © 2012 HealthDay. All rights reserved.

send feedback to editors
not rated yet  

Rank not rated yet
Tags

nasal polyps, immune reaction, methylprednisolone, interleukin, secretion, cavities, serum, allergy, patients, tissue
Related Stories
more news
Relevant PhysicsForums posts

More news stories

Stem-cell-based strategy boosts immune system in mice

Raising hopes for cell-based therapies, UC San Francisco researchers have created the first functioning human thymus tissue from embryonic stem cells in the laboratory. The researchers showed that, in mice, ...

Immunology created May 16, 2013 | popularity 4.8 / 5 (5) | comments 0 | with audio podcast

Resistance to visceral leishmaniasis: New mechanisms involved

Researchers from CNRS, Université Toulouse III - Paul Sabatier and IRD have elucidated new molecular mechanisms involved in resistance to visceral leishmaniasis, a serious parasitic infection. They have shown that dectin-1 ...

Immunology created May 16, 2013 | popularity not rated yet | comments 0

Women's immune systems remain younger for longer

Women's immune systems age more slowly than men's, suggests research in BioMed Central's open access journal Immunity & Ageing. The slower decline in a woman's immune system may contribute to women living longer than men. ...

Immunology created May 14, 2013 | popularity not rated yet | comments 0

Newly described type of immune cell and T cells share similar path to maturity, according to new study

(Medical Xpress)—Labs around the world, and a core group at Penn, have been studying recently described populations of immune cells called innate lymphoid cells (ILCs). Some researchers liken them to foot soldiers that ...

Immunology created May 14, 2013 | popularity 5 / 5 (3) | comments 0 | with audio podcast

Not all cytokine-producing cells start out the same way, study finds

(Medical Xpress)—Cytokines are molecules produced by immune cells that induce the migration of other cells to sites of infection or injury, promote the production of anti-microbial agents, and signal the production of inflammatory ...

Immunology created May 13, 2013 | popularity 5 / 5 (1) | comments 0 | with audio podcast


Researchers identify a potential new risk for sleep apnea: Asthma

Researchers at the University of Wisconsin have identified a potential new risk factor for obstructive sleep apnea: asthma. Using data from the National Institutes of Health (Heart, Lung, and Blood Institute)-funded Wisconsin ...

Study finds that sleep apnea and Alzheimer's are linked

A new study looking at sleep-disordered breathing (SDB) and markers for Alzheimer's disease (AD) risk in cerebrospinal fluid (CSF) and neuroimaging adds to the growing body of research linking the two.

Computational tool translates complex data into simplified 2-dimensional images

In their quest to learn more about the variability of cells between and within tissues, biomedical scientists have devised tools capable of simultaneously measuring dozens of characteristics of individual ...

New theory on genesis of osteoarthritis comes with successful therapy in mice

Scientists at Johns Hopkins have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, ...

Ginger compounds may be effective in treating asthma symptoms

Gourmands and foodies everywhere have long recognized ginger as a great way to add a little peppery zing to both sweet and savory dishes; now, a study from researchers at Columbia University shows purified components of the ...

'Gap' for HIV vaccine efforts after latest setback

The hunt for an HIV vaccine has gobbled up $8 billion in the past decade, and the failure of the most recent efficacy trial has delivered yet another setback to 26 years of efforts.