Free light chains identified in chronic rhinosinusitis

Free light chains identified in chronic rhinosinusitis
Patients with chronic rhinosinusitis (CRS) have increased free light chain concentrations, particularly those with CRS with nasal polyps, according to a study published online July 5 in Allergy.

(HealthDay) -- Patients with chronic rhinosinusitis (CRS) have increased free light chain (FLC) concentrations, particularly those with CRS with nasal polyps (CRSwNP), according to a study published online July 5 in Allergy.

Tom Groot Kormelink, of Utrecht University in the Netherlands, and associates analyzed nasal tissue, nasal , and serum of patients with CRSwNP and CRS without nasal polyps (CRSsNP) to determine the presence of FLCs. The effect of different treatments on the expression of FLCs was examined.

The researchers found that patients with CRS had increased FLC concentrations in nasal secretion and mucosal tissue homogenates, and the increase was most prominent in patients with CRSwNP. The increase in FLC in nasal polyp tissue was confirmed by immunohistochemistry. Treatment with methylprednisolone or anti--5 (IL-5) resulted in the reduction in systemic or local FLC concentrations, respectively, in patients with CRSwNP.

"The presence of FLC in CRSwNP and CRSsNP suggests a possible role in mediating the local in the paranasal ," the authors write. "Furthermore, the decrease in local FLCs after treatment with anti-IL-5 presumes that IL-5 creates an environment that favors FLC production."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

IL-32 expression upregulated in chronic rhinosinusitis

Apr 17, 2012

(HealthDay) -- Interleukin-32 (IL-32) mRNA expression is significantly higher in biopsies obtained from patients with chronic rhinosinusitis (CRS), compared to levels found in biopsies obtained from individuals ...

Study: No link between depression, nasal obstruction

Apr 19, 2012

While mood disorders like depression or anxiety tend to negatively affect treatment for allergies and chronic rhinosinusitis, the same cannot be said for patients with nasal obstructions such as deviated septum, according ...

Recommended for you

Could trophoblasts be the immune cells of pregnancy?

Dec 18, 2014

Trophoblasts, cells that form an outer layer around a fertilized egg and develop into the major part of the placenta, have now been shown to respond to inflammatory danger signals, researchers from Norwegian University of ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.