Researchers investigating potential drug for treatement of Alzheimer's disease

A compound developed to treat neuropathic pain has shown potential as an innovative treatment for Alzheimer's disease, according to a study by researchers at Cleveland Clinic's Lerner Research Institute and Anesthesiology Institute.

"Cleveland Clinic dedicated two years of research into the examination of this compound and our findings show it could represent a novel in the treatment of Alzheimer's disease," said Mohamed Naguib, M.D., Professor of Anesthesiology, Cleveland Clinic Lerner College of Medicine. "Development of this compound as a potential drug for Alzheimer's would take many more years, but this is a promising finding worthy of further investigation."

In a study published online in the Neurobiology of Aging, the compound MDA7 induced beneficial immune responses that limited the development of Alzheimer's disease. Treatment with the compound restored cognition, memory and synaptic plasticity – a key neurological foundation of – in an .

Neuroinflammation is an important mechanism involved in the progression of Alzheimer's disease. The MDA7 compound has anti-inflammatory properties that act on the CB2 receptor – one of the two in the body – but without the negative side effects normally seen with cannabinoid compounds.

Alzheimer's disease is an irreversible, that slowly destroys memory and thinking skills. About 5 million people in the United States have Alzheimer's disease. With the aging of the population, and without successful treatment, there will be 16 million Americans and 106 million people worldwide with Alzheimer's by 2050, according to the 2011 Alzheimer's Disease Facts and Figures report from the Alzheimer's Association.

add to favorites email to friend print save as pdf

Related Stories

Alzheimer's disease now 100 years old

Oct 30, 2006

Many of the world's Alzheimer's disease experts will be in Cleveland next week to observe the 100th anniversary of the first Alzheimer's disease diagnosis.

Researchers find new Alzheimer's disease treatment promising

Jul 12, 2009

Researchers at Mount Sinai School of Medicine have found that a compound called NIC5-15, might be a safe and effective treatment to stabilize cognitive performance in patients with mild to moderate Alzheimer's disease. The ...

Alzheimer's disease to quadruple worldwide by 2050

Jun 10, 2007

More than 26 million people worldwide were estimated to be living with Alzheimer’s disease in 2006, according to a study led by researchers at the Johns Hopkins Bloomberg School of Public Health. The researchers also concluded ...

Recommended for you

Researchers identify potential biomarker for AD

Jul 28, 2014

Researchers from Boston University School of Medicine (BUSM) report variants in a new gene, PLXNA4, which may increase the risk of developing Alzheimer's disease (AD). The discovery of this novel genetic association may lead ...

Study links enzyme to Alzheimer's disease

Jul 21, 2014

Unclogging the body's protein disposal system may improve memory in patients with Alzheimer's disease (AD), according to a study from scientists at Kyungpook National University in Korea published in The Jo ...

User comments