Taxane-induced neuropathy not tied to breast cancer outcome

August 2, 2012
Taxane-induced neuropathy not tied to breast cancer outcome
For patients with operable breast cancer, peripheral neuropathy due to adjuvant taxane therapy does not correlate with improved outcomes, according to research published online July 30 in the Journal of Clinical Oncology.

(HealthDay) -- For patients with operable breast cancer, peripheral neuropathy due to adjuvant taxane therapy does not correlate with improved outcomes, according to research published online July 30 in the Journal of Clinical Oncology.

Bryan P. Schneider, M.D., of the Eastern Cooperative Oncology Group in Indianapolis, and colleagues conducted a study involving 4,554 women with operable who received chemotherapy (up to four cycles of doxorubicin and cyclophosphamide every three weeks) followed by either paclitaxel every three weeks for four cycles (P3), paclitaxel weekly for 12 cycles (P1), docetaxel every three weeks for four cycles (D3), or docetaxel every week for 12 cycles (D1).

The researchers found that grade 2 to 4 neuropathy occurred in 18, 22, 15, and 13 percent of patients who received at least one taxane dose in the P3, P1, D3, and D1 arms of the study, respectively. No significant relationship was observed between the development of neuropathy and disease-free survival, overall survival, or recurrence-free survival, in a model including age, race, obesity, menopausal status, , nodal status, treatment group, neuropathy, and hyperglycemia.

"Taxane-induced does not correlate with improved outcomes in patients with operable breast cancer treated with adjuvant taxane therapy," the authors write. "This finding provides reassurance that biomarkers predictive for neuropathy will likely not enrich for patients who are more likely to benefit from taxane therapy and may also be useful for the identification of patients who are most likely to benefit from adjunctive therapies to mitigate neuropathy."

Several authors disclosed to the pharmaceutical industry.

Explore further: Some breast cancer tumors may be resistant to a common chemotherapy treatment

More information: Abstract
Full Text (subscription or payment may be required)
Editorial

Related Stories

Recommended for you

Shape of tumor may affect whether cells can metastasize

April 28, 2016

Only a few cells in a cancerous tumor are able to break away and spread to other parts of the body, but the curve along the edge of the tumor may play a large role in activating these tumor-seeding cells, according to a new ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.