Taxane-induced neuropathy not tied to breast cancer outcome

Taxane-induced neuropathy not tied to breast cancer outcome
For patients with operable breast cancer, peripheral neuropathy due to adjuvant taxane therapy does not correlate with improved outcomes, according to research published online July 30 in the Journal of Clinical Oncology.

(HealthDay) -- For patients with operable breast cancer, peripheral neuropathy due to adjuvant taxane therapy does not correlate with improved outcomes, according to research published online July 30 in the Journal of Clinical Oncology.

Bryan P. Schneider, M.D., of the Eastern Cooperative Oncology Group in Indianapolis, and colleagues conducted a study involving 4,554 women with operable who received chemotherapy (up to four cycles of doxorubicin and cyclophosphamide every three weeks) followed by either paclitaxel every three weeks for four cycles (P3), paclitaxel weekly for 12 cycles (P1), docetaxel every three weeks for four cycles (D3), or docetaxel every week for 12 cycles (D1).

The researchers found that grade 2 to 4 neuropathy occurred in 18, 22, 15, and 13 percent of patients who received at least one taxane dose in the P3, P1, D3, and D1 arms of the study, respectively. No significant relationship was observed between the development of neuropathy and disease-free survival, overall survival, or recurrence-free survival, in a model including age, race, obesity, menopausal status, , nodal status, treatment group, neuropathy, and hyperglycemia.

"Taxane-induced does not correlate with improved outcomes in patients with operable breast cancer treated with adjuvant taxane therapy," the authors write. "This finding provides reassurance that biomarkers predictive for neuropathy will likely not enrich for patients who are more likely to benefit from taxane therapy and may also be useful for the identification of patients who are most likely to benefit from adjunctive therapies to mitigate neuropathy."

Several authors disclosed to the pharmaceutical industry.

More information: Abstract
Full Text (subscription or payment may be required)
Editorial

add to favorites email to friend print save as pdf

Related Stories

Docetaxel given after doxorubicin reduces recurrence

Jan 08, 2008

Adding the drug docetaxel to anthracycline-based chemotherapy slightly improved disease-free survival in breast cancer patients, according to a randomized clinical trial published online January 8 in the Journal of the Na ...

Recommended for you

Discovery could lead to new cancer treatment

Aug 29, 2014

A team of scientists from the University of Colorado School of Medicine has reported the breakthrough discovery of a process to expand production of stem cells used to treat cancer patients. These findings could have implications ...

Is the HPV vaccine necessary?

Aug 29, 2014

As the school year starts in full swing many parents wonder if their child should receive the HPV vaccine, which is recommended for girls ages 11-26 and boys 11-21. There are a lot of questions and controversy around this ...

User comments