Genetic research addresses fatalities due to sepsis
September 17, 2012 in Medical research
Credit: Thinkstock
The genetics of a patient affects the extent of septic shock development and response to therapy. European researchers have identified genes related to sepsis in a study group of more than 2,500 patients in Europe.
Septic shock is a condition that occurs as a result of severe infection to cause a systemic inflammatory response. Fatality from sepsis is high and mainly affects children, the elderly and those with a compromised immune system.
The 'Genetics of sepsis in Europe' (Genosept) project aimed to raise clinical awareness of how a patient's genes may affect important variables like response to treatment and possibility of fatal outcome. To achieve this goal, project scientists defined novel candidate genes linked to the condition using expression studies. The identified genes were then analysed in relation to predisposition to sepsis-related mortality in European intensive care units.
Genosept scientists have established a system whereby future data can be recorded and therefore pooled in a database for further analysis. An electronic case report form (eCRF) provides details of each patient. Each eCRF is verified for quality and information content.
Most important for genotyping was the identification and evaluation of relevant candidate genes and their markers related to sepsis. Project researchers also developed processes and systems for blood sampling and genotyping tests.
Statistical analysis of the data linked the genetic variants identified with probability of mortality. Furthermore, the analysis pointed to associations between patient genes and phenotype related to sepsis outcomes.
Genosept has built a bridge between genomics and intensive care clinicians involved in this often fatal condition. Application of data means that expensive treatments for septic shock may be focused on high-risk patients. Standardisation of protocols also may be translated into the reduction of sepsis-related mortality.
Provided by
CORDIS
-
Sepsis campaign improving treatment of major killer
Jan 13, 2010 |
not rated yet |
0
-
Study examines sepsis and septic shock after surgery
Jul 19, 2010 |
not rated yet |
0
-
Surviving sepsis program -- increased compliance gets results
Sep 03, 2009 |
not rated yet |
0
-
Early identification and treatment of septic shock to save lives
Jun 01, 2012 |
not rated yet |
0
-
Therapy helps improve outcomes for patients with severe sepsis
Jun 17, 2009 |
not rated yet |
0
-
Motion perception revisited: High Phi effect challenges established motion perception assumptions
Apr 23, 2013 |
3 / 5 (2) |
2
-
Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update)
Apr 02, 2013 |
4.5 / 5 (11) |
5
-
The visual system as economist: Neural resource allocation in visual adaptation
Mar 30, 2013 |
5 / 5 (2) |
9
-
Separate lives: Neuronal and organismal lifespans decoupled
Mar 27, 2013 |
4.9 / 5 (8) |
0
-
Sizing things up: The evolutionary neurobiology of scale invariance
Feb 28, 2013 |
4.8 / 5 (10) |
14
-
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013
-
If you became brain-dead, would you want them to pull the plug?
May 17, 2013
-
MRI bill question
May 15, 2013
-
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013
-
Alcohol and acetaminophen
May 13, 2013
-
Marie Curie's leukemia
May 13, 2013
- More from Physics Forums - Medical Sciences
More news stories
New study finds blind people have the potential to use their 'inner bat' to locate objects
New research from the University of Southampton has shown that blind and visually impaired people have the potential to use echolocation, similar to that used by bats and dolphins, to determine the location of an object.
Medical research
1 hour ago |
not rated yet |
1
|
Germ-fighting vaccine system makes great strides in delivery
A novel vaccine study from South Dakota State University (SDSU) will headline the groundbreaking research that will be unveiled at the American Association of Pharmaceutical Scientists' (AAPS) National Biotechnology Conference ...
Medical research
2 hours ago |
not rated yet |
0
Discovery of novel medicine for treatment of chronic wounds
Every 20 seconds, a limb is lost as a consequence of diabetic foot ulcer that does not heal. To date, medical solutions that can change this situation are very limited. In his doctoral thesis Yue Shen from the Industrial ...
Medical research
6 hours ago |
5 / 5 (1) |
0
Lymphatic fluid takes detour
When tumours metastasise, they can block lymphatic vessels, as researchers from ETH Zurich have discovered using a new method. The lymphatic fluid subsequently has to find a new path through the tissue. Such ...
Medical research
6 hours ago |
not rated yet |
0
|
Computational tool translates complex data into simplified 2-dimensional images
In their quest to learn more about the variability of cells between and within tissues, biomedical scientists have devised tools capable of simultaneously measuring dozens of characteristics of individual ...
Medical research
May 19, 2013 |
5 / 5 (3) |
0
|
Music therapy reduces anxiety, use of sedatives for patients receiving ventilator support
New research suggests that for some hospitalized ICU patients on mechanical ventilators, using headphones to listen to their favorite types of music could lower anxiety and reduce their need for sedative medications.
Tiny, implantable coil promises hope for emphysema patients
A small, easily implantable device called the Lung Volume Reduction Coil (LVRC) may play a key role in the treatment of two types of emphysema, according to a study conducted in Europe. Results of the study indicate the beneficial ...
Early IV nutrition for certain patients does improve survival or reduce ICU length of stay
The early (within 24 hours of intensive care unit [ICU] admission) provision of intravenous nutrition among critically ill patients with contraindications (a condition that makes a particular procedure potentially inadvisable) ...
Having a nighttime critical care physician in the ICU doesn't improve patient outcomes, research finds
With little evidence to guide them, many hospital intensive care units (ICUs) have been employing critical care physicians at night with the notion it would improve patients' outcomes. However, new results from a one-year ...
Extra vitamin D may ease Crohn's symptoms, study finds
(HealthDay)—Vitamin D supplements may help those with Crohn's disease overcome the fatigue and decreased muscle strength associated with the inflammatory bowel disease, according to new research.
Digital divide exists with physician EHR adoption
(HealthDay)—The majority of physicians remain reluctant to adopt health information technology (HIT), according to a report by Deloitte Touche Tohmatsu.