Daily vibration may combat prediabetes in youth
Daily sessions of whole-body vibration may combat prediabetes in adolescents, dramatically reducing inflammation, average blood glucose levels and symptoms such as frequent urination, researchers report.
In mice that mimic over-eating adolescents headed toward diabetes, 20 minutes of daily vibration for eight weeks restored a healthy balance of key pro- and anti-inflammatory mediators and was better than prescription drugs at reducing levels of hemoglobin A1c, the most accurate indicator of average blood glucose levels, said Dr. Jack C. Yu, Chief of the Section of Plastic and Reconstructive Surgery at the Medical College of Georgia at Georgia Health Sciences University.
In normal mice, just four days of vibration also dramatically improved the ability to manage a huge glucose surge similar to that following a high-calorie, high-fat meal. "It's a very good sign," said Yu. "If you eat a pound of sugar, your blood glucose will go up. If you are prediabetic, it will go up even more and take longer to come down."
Interestingly, vibration did not produce similar changes in older, normal mice, Yu told researchers at the Third World Congress of Plastic Surgeons of Chinese Descent.
"This is our model: the average American teenager who eats too much," said Yu, who regularly operates on obese and often prediabetic adolescent males who want their abnormally large breasts reduced. "The only way to burn fat is to exercise. We shake the bone for you rather than the body's muscle shaking it. This is a highly efficient way to fool the bone into thinking we are exercising."
It's also one way to deal with the reality that many individuals simply will not exercise regularly, he said.
Yu, also a craniofacial surgeon who studies bone formation, said while it's unclear exactly how vibration produces these desirable results, it seems linked to the impact of movement on bone health. Vibration mimics the motion bones experience during exercise when muscles are doing the work. The slight bending and unbending of bone triggers remodeling so it can stay strong. One result is production of osteocalcin, a protein essential to bone building, which also signals the pancreas to get ready for food. While this prehistoric relationship is tied to the hunt for food, it doesn't work so well in 21st century living where folks are moving too little and eating too much, Yu said. The constant demand can produce resistance to the insulin required to use glucose as energy.
Additionally, the body tends to hold onto fat for energy and survival, which researchers think is key to the chronic inflammation found in obesity-related type 2 diabetes. The fat itself produces inflammatory factors; the immune system also can misidentify fat as an infection, resulting in even more inflammation but, unfortunately, not eliminating the fat.
The bottom line is an unbalanced immune response: too many aggressors like the immune system SWAT team member Th17 and too few calming regulating factors like FoxP3. Researchers looked in the mouse blood and found vibration produced a 125-fold increase in immune system homeostasis and similar results in the kidney. This included positive movement in other players as well, such as a five-fold reduction in what Yu calls the "nuclear fuel," gammaH2AX, an indicator that something is attacking the body's DNA.
The animal model researchers used has a defect in the receptor for leptin, the satiety hormone, so the mice uncharacteristically overeat. Vibration also significantly reduced the mouse's diabetic symptoms of excessive thirst and diluted urine, resulting from excessive urination. The mice also seemed to like it, Yu said.
Next steps include learning more about how vibration produces such desirable results and large-scale clinical studies to see if they hold true in adolescents.
Prediabetics can avoid type 2 diabetes by making healthy diet changes and increasing physical activity, according to the American Diabetes Association.
Vibration technology was originally developed by the former Soviet Union to try to prevent muscle and bone wasting in cosmonauts. MCG researchers reported in the journal Bone in 2010 that daily whole body vibration may help minimize age-related bone density loss.
Yu and Biomedical Engineer Karl H. Wenger developed the whole-body vibrator used for the animal studies. Study coauthors include Wenger as well as GHSU's Drs. Babak Baban, Sun Hsieh, Mahmood Mozaffari and Mohamad Masoumy.
Provided by Georgia Health Sciences University
- Daily vibration may help aging bones stay healthy Oct 25, 2010 | not rated yet | 0
- Study: Vibration Exercise Slows Weight Gain Aug 25, 2008 | not rated yet | 0
- Exercise can produce healthy chatter between bone, fat and pancreatic cells Sep 19, 2011 | not rated yet | 0
- Exercise boosts health by influencing stem cells to become bone, not fat, researchers find Sep 01, 2011 | not rated yet | 0
- A diabetes drug, sitagliptin, also has a potential to prevent diabetes Mar 24, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Learning curve of Electromagnetism?
2 hours ago I'm taking a first year physics course and have been having a little trouble with the basics of newtons laws and forces and whatnot, though nothing...
thin glass in liquid
3 hours ago I have one question about optics because I start interested in it. If an object is placed a distance p from a thin glass lens (index of refraction...
How many joules expended for a push up?
6 hours ago Just wondering if any of you can do the calculation that well approximates the amount of joules expended by a push up.
force to keep the folding doors
6 hours ago Hello, I would like to ask you to calculate the force F, which needed to keep the folding doors in this position. I would like to know what is the...
Confusion regarding direction of kinetic friction on inclined plane.
7 hours ago *please help! * The formula for kinetic friction acting on a sliding body is μkN When the body is sliding with constant velocity down an...
13 hours ago Alright, so in Pathfinder (like Dungeons and Dragons) there's a spell that allows you to lift/move stuff within 25 ft with 5 pounds of force. A...
- More from Physics Forums - Classical Physics
More news stories
(HealthDay)—Moderate aerobic exercise prevents fructose-induced hypertriglyceridemia in healthy males, according to a study published online May 14 in Diabetes.
Diabetes May 17, 2013 | 5 / 5 (1) | 0 |
A DNA variant near a digestive enzyme does not only affect risk of developing diabetes but also affects the response to treatment, an international consortium of researchers including the University of Dundee has found.
Diabetes May 17, 2013 | not rated yet | 0 |
(Medical Xpress)—Development of a sophisticated artificial pancreas holds potential to transform the lives of patients with Type 1 diabetes.
Diabetes May 16, 2013 | 5 / 5 (1) | 0 |
A small University at Buffalo study has found for the first time that in Type 1 diabetics, insulin injections exert a strong anti-inflammatory effect at the cellular and molecular level, while even small amounts of glucose ...
Diabetes May 16, 2013 | not rated yet | 0
(HealthDay)—Home diabetes regimens partially explain the increased risk of having a hypoglycemia event during hospitalization among older African-American men with diabetes, according to a study published ...
Diabetes May 14, 2013 | not rated yet | 0
An increasing number of U.S. children are experiencing gastrointestinal issues that require interventions to resolve, according to research presented at Digestive Disease Week (DDW).
6 hours ago | not rated yet | 0 |
Big names in medicine are set to give an upbeat assessment of the war on AIDS on Tuesday, 30 years after French researchers identified the virus that causes the disease.
14 hours ago | 5 / 5 (1) | 0
For combat veterans suffering from post-traumatic stress disorder, 'fear circuitry' in the brain never rests
Chronic trauma can inflict lasting damage to brain regions associated with fear and anxiety. Previous imaging studies of people with post-traumatic stress disorder, or PTSD, have shown that these brain regions can over-or ...
15 hours ago | 5 / 5 (1) | 0 |
The latest makeover to a massive psychiatric tome honored by some, reviled by others and even called the "Bible" of mental disorders is being released Saturday with a host of new changes.
4 hours ago | not rated yet | 0
A new case of the deadly coronavirus has been detected in Saudi Arabia where 15 people have already died after contracting it, the health ministry announced on Saturday on its Internet website.
4 hours ago | not rated yet | 0
A ground-breaking advance in colonoscopy technology signals the future of colorectal care, according to research presented today at Digestive Disease Week(DDW). Additional research focuses on optimizing the minimal withdrawal ...
6 hours ago | 5 / 5 (1) | 0