Moderately dysplastic nevi re-excision not necessary

November 12, 2012
Moderately dysplastic nevi re-excision not necessary
Re-excision of mildly or moderately histologically dysplastic nevi that approach a microscopic border may not be necessary, as favorable long-term outcomes are achieved without re-excision, according to a study published online Nov. 5 in the Journal of the American Academy of Dermatology.

(HealthDay)—Re-excision of mildly or moderately histologically dysplastic nevi (HDN) that approach a microscopic border may not be necessary, as favorable long-term outcomes are achieved without re-excision, according to a study published online Nov. 5 in the Journal of the American Academy of Dermatology.

Thomas Hocker, M.D., of the in Rochester, Minn., and colleagues conducted a involving 115 patients who had an HDN that extended to within 0.2 mm of a microscopic punch, shave, or excision border and was not re-excised. The rate of melanoma development was assessed over time.

Of the 115 dysplastic , 66 were mildly dysplastic, 42 were moderately dysplastic, and seven were severely dysplastic. During an average follow-up of 17.4 years, the researchers found that no patient developed metastatic melanoma or melanoma at the site of removal of an HDN, including in the 63.4 percent of patients followed for more than 20 years.

"The long-term outcomes in our cohort provide evidence that routine re-excision of HDNs with mild or moderate dysplasia may not be necessary, if the entire clinically visible lesion is removed, even if the nevus approaches a histologic margin," the authors write. "Avoiding re-excision of these nevi encountered in daily practice would result in fewer surgical procedures, with associated decreases in morbidity, including cosmetic disfigurement, and health care utilization and costs."

Explore further: Pathologists tend to reclassify prior nonmalignant diagnoses

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Pathologists tend to reclassify prior nonmalignant diagnoses

August 17, 2012

(HealthDay) -- For dermatopathologists there is a trend toward reclassification of prior nonmalignant diagnoses of severely atypical dysplastic nevi as malignant, according to a study published in the September issue of the ...

Negative pigment network able to distinguish melanoma

October 25, 2012

(HealthDay)—Negative pigment network (NPN) can be used to distinguish melanoma from Spitz nevus and other benign lesions, according to a study published online Oct. 11 in the Journal of the American Academy of Dermatology.

Recommended for you

Re-emergence of syphilis traced to pandemic strain cluster

December 5, 2016

Over the last few decades, an age-old infectious disease has been re-emerging globally: syphilis. Using techniques to analyze low levels of DNA, an international research team headed by the University of Zurich has now shown ...

New mechanism to control human viral infections discovered

December 5, 2016

A team of researchers, co-led by a University of California, Riverside professor, has found a long-sought-after mechanism in human cells that creates immunity to influenza A virus, which causes annual seasonal epidemics and ...

Researcher making headway in fighting migraines

December 5, 2016

A study by a UT Dallas researcher has revealed new information about a potential chemical causing pain hypersensitivity in migraines, which is the third most common disease in the world.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.