Successful pregnancy outcomes in women with cystic fibrosis

Successful pregnancy outcomes in women with cystic fibrosis
Women with cystic fibrosis can have successful pregnancies, according to research published online Nov. 12 in BJOG: An International Journal of Obstetrics and Gynaecology.

(HealthDay)—Women with cystic fibrosis (CF) can have successful pregnancies, according to research published online Nov. 12 in BJOG: An International Journal of Obstetrics and Gynaecology.

J. Guy Thorpe-Beeston, M.D., from the Chelsea and Westminster Foundation Trust in London, and colleagues retrospectively reviewed maternity case notes to describe maternal and fetal outcomes from 48 pregnancies in 41 women with CF.

In the cohort, the researchers note that there were 44 singleton pregnancies and two sets of twins, all of whom were liveborn and survived, and two miscarriages. At delivery, the mean gestational age was 35.9 ± 3.3 weeks and the median birth weight centile was 31.9. Pancreatic insufficiency was present in 52.1 percent of the women, with 35.4 percent requiring insulin. Booking predicted forced expiratory volume in 1 second () was significantly positively correlated with gestational age at delivery. Women were more likely to deliver earlier (35.0 ± 3.2 weeks versus 37.1 3.0 weeks; P = 0.02) and by cesarean section (75.0 versus 25.0 percent; P = 0.01) if their FEV1 was ≤60 percent, compared with women with FEV1 >60 percent. Of the seven women with FEV1 of <40 percent, three died within 18 months of delivery, while four of the eight women with FEV1 of 40 to 50 percent died between two and eight years after delivery.

"Modern obstetric and CF management, together with expert neonatal and anesthetic services, have combined to enable women with CF to have successful pregnancies without apparent significant deterioration of their lung function," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

No increase in preterm delivery with Ramadan fasting

Aug 07, 2012

(HealthDay) -- Pregnant women who fast during the month of Ramadan do not have an increased risk of preterm delivery, regardless of when during gestation the fasting occurs, according to research published ...

Risk of post-cesarean infection up for overweight, obese

Sep 26, 2012

(HealthDay)—About 10 percent of U.K. women who undergo cesarean section develop a surgical site infection, with the odds significantly increased for overweight or obese women, according to a study published ...

Recommended for you

Vitamin D may not prevent return of vaginosis after all

21 hours ago

(HealthDay)—A new study suggests that high doses of vitamin D may not help prevent the return of bacterial vaginosis (BV). The research was published in the November issue of the American Journal of Obstetrics and Gynecology.

Eating disorders linked to adverse perinatal outcomes

Oct 22, 2014

(HealthDay)—Maternal eating disorders are associated with adverse pregnancy, obstetric, and perinatal health outcomes, according to a study published in the October issue of the American Journal of Obstetrics & ...

Large variation in cesarean rates across US hospitals

Oct 21, 2014

Cesarean delivery is the most common inpatient surgery in the United States. US cesarean rates increased from 20.7% in 1996 to 32.9% in 2009 but have since stabilized, with 1.3 million American women having had a cesarean ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.